Abstract:Intensity-modulated radiation therapy (IMRT) is an exciting new advance in the practice of radiation oncology. It is the use of non-uniform radiation beams to achieve conformal dose distributions. As a result of the high initial capital costs and the time and complexity of planning, IMRT is not yet a widely available clinical treatment option. We describe the process involved in applying this new technology to a case of locally advanced nasopharyngeal cancer.
“…dose to reach the target with maximal sparing of the dose to the normal tissues. The treatment system involves the use of multileaf collimators, which divide each beam into many small segments that are each weighted such that the overall beam intensity pattern achieves the desired target coverage and critical tissue sparing (16,17).…”
“…dose to reach the target with maximal sparing of the dose to the normal tissues. The treatment system involves the use of multileaf collimators, which divide each beam into many small segments that are each weighted such that the overall beam intensity pattern achieves the desired target coverage and critical tissue sparing (16,17).…”
“…Intensity-modulated radiation treatment allows for maximal shielding of uninvolved tissues and is an exciting prospect. 24,25 Patient immobilization and contemporary 3-dimensional conformal planning are required to tightly define treatment volumes with fraction sizes compatible with longterm cerebral and vascular function.…”
Section: Perineural Spread Of Scc Involving the Ocular Adnexaementioning
The diagnosis of perineural spread is largely clinical and may be confirmed with imaging findings in the majority of cases. The role of biopsy is usually complementary but may be essential in some cases. In patients with evidence of distant perineural spread, radiotherapy volumes inclusive of potential antegrade and retrograde spread are recommended. Three-dimensional conformal planning or intensity-modulated radiation therapy assists in minimizing damage to adjacent structures. Synchronous chemotherapy should be considered to potentiate the effectiveness of radiation. The place of surgery in the treatment of perineural spread is palliative.
“…Since the earliest reported delivery a modulated radiotherapy treatment in Australia and New Zealand in 2002 [12], the use of inverse planning has progressed to the point that most if not all centres in Australia and New Zealand are now treating with modulated techniques. The delivery of increasingly complex treatments to smaller targets has placed demands on physics time (with all treatments requiring patient-specific quality assurance testing) and has required vendors and individuals to develop more sophisticated one-, two-and threedimensional dosimeters, and to fabricate more specialised phantoms.…”
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