Intensity Dependence of Auditory Evoked N1/P2 Component and Personality

Hegerl, Ulrich; Karnauchow, I; Herrmann, Wiebke; Müller‐Oerlinghausen, B.

doi:10.1159/000118912

Cited by 16 publications

(7 citation statements)

References 18 publications

(20 reference statements)

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“…This change is also referred to as augmenting disposition or 'high-level intensity dependence'. Since Zuckerman's [1] review, this finding has been replicated several times [2,3]. In a recent study, we could also confirm the correlation between SS and augmenting [4].…”

Section: Introductionsupporting

confidence: 62%

“…However, because the use of regression slopes for the amplitude stimulus intensity function (ASF) has been criticized for their low coefficients of determination in individual data [20], a nonlinear computation was also performed [2]. The medians of all possible slopes between each two amplitudes for the six stimulus intensities (median slopes) were calculated.…”

Section: Discussionmentioning

confidence: 99%

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Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

et al. 2000

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Augmenting/reducing of the evoked potential has been shown to be related to sensation seeking (SS) and specific clinical disorders. Buchsbaum demonstrated that patients with bipolar affective disorders (BAD) tend to be augmenters, as is the case with sensation seekers, and patients with unipolar affective disorders (UPD) tend to be reducers. In addition, he reported that prophylactic medication reduced the tendency to augment in bipolar patients. However, evidence for these relations is restricted to a few studies. This study explores whether Buchsbaum’s initial findings can be found in a naturalistic clinical setting. Acoustic evoked potentials were recorded for six levels of intensity (59, 71, 79, 88, 92, 96 dB SPL) from 24 healthy adults, 21 unipolar depressed patients, and 21 patients with BAD. Participants also completed personality questionnaires, especially the Sensation Seeking Scales Form V. Results revealed a positive correlation between SS and augmenting/reducing in healthy controls, thereby replicating earlier findings. Bipolar depressed patients showed larger P1/N1 slopes than healthy controls, when medication was statistically controlled. Unipolar depressed patients showed smaller P2 slopes, but only when medication was not controlled. Implications of these results for further research on augmenting/reducing and affective disorders and their relationship to SS are discussed.

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Section: Introductionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

et al. 2000

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“…* Supporting the interpretation of these ERP response profiles, studies have found that the temperament traits of extraversion [4] and novelty- [5] and sensation- [6][7][8] seeking are associated with increased intensity dependence.…”

Section: Introductionmentioning

confidence: 90%

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Metzger

Pitman²,

Miller³

et al. 2008

JRRD

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Abstract-Two studies have reported decreased intensity dependence of the P2 event-related potential (ERP) in male combat veterans with posttraumatic stress disorder (PTSD), a response pattern presumed to reflect central nervous systeminduced protective inhibition and heightened central serotonergic activity. We used an identical twin, case-control design to investigate whether intensity dependence abnormalities reflect pretrauma vulnerability or are an acquired consequence of PTSD. ERPs were measured in male Vietnam combat veterans and their noncombat-exposed monozygotic twin brothers during a four-tone, stimulus-intensity modulation procedure. Contrary to previous findings in male veterans, the PTSD group had significantly steeper P2 amplitude intensity slopes, similar to those reported for female veterans and abused children with PTSD. Additionally, increased P2 amplitude intensity slope was associated with increased PTSD symptom severity, particularly the severity of reexperiencing symptoms. A mixed-model, random-effects analysis that included the combat-unexposed twins revealed a significant diagnosis by combat exposure interaction. Inspection of group means suggests that the observed increased P2 intensity dependence is a consequence of PTSD. Our findings further suggest that low serotonergic tone may emerge as one potential consequence of this disorder.

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“…For a retest of IDAP within the same test session, i.e. a second recording after about 20 min, Hegerl et al (16) reported a pronounced drop in ASF slopes for a subgroup of their volunteers. This is in line with our results showing a significant decrease of mean ASF slopes in the second measurement of the I-h retest when a 100 Hz low-pass filter was used and a nonsignificant but strong tendency in the same direction using a 30 Hz filter.…”

Section: Mean Asf Slopes (Table 1)mentioning

confidence: 99%

Repeatability of the Intensity Dependence of Cortical Auditory Evoked Potentials in the Assessment of Cortical Information Processing

et al. 1999

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Data on repeatability and optimal settings are needed when studying the influence of drugs on the intensity dependence of auditory evoked cortical potentials (IDAP). IDAP was recorded at intervals of 1, 2, and 24 h at two centers in 22 healthy volunteers. Settings were modified to compare fixed versus randomly varied stimulus repetition rate, as well as 30 Hz and 100 Hz low pass filters. Repeatability was assessed for different intervals and different settings. Group means did not differ between centers, the 2-h or 24-h retest, or when using different settings. We observed an order effect for the 1 h retest. Fixed repetition rate and the 30 Hz filter improved repeatability with still high intraindividual variability. IDAP group means can be compared between centers for retest intervals of 2 h and 24 h and different settings. Variability is too large to compare individuals.

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Intensity Dependence of Auditory Evoked N1/P2 Component and Personality

Cited by 16 publications

References 18 publications

Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

Sensation Seeking and Affective Disorders: Characteristics in the Intensity Dependence of Acoustic Evoked Potentials

Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: Associations with posttraumatic stress disorder

Repeatability of the Intensity Dependence of Cortical Auditory Evoked Potentials in the Assessment of Cortical Information Processing

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