“…However, membrane fouling during the process is one of the major disadvantages of this technology (4). Different techniques might be employed to reduce the membrane fouling: increase of crossflow velocity (5), promotion of turbulence (6,7,8,9,10), pulsation, backflushing (11), temperature increase (12), changes in pH (13), flocculation (14,15), and coagulation (16) of the suspension, introduction of external electrical field (17,18), and surface modification with temperature sensitive polymers (19). Membrane fouling becomes even more critical in crossflow microfiltration of disrupted cells as there are solids and solutes of various sizes, hydrophobicities, charge densities, solubilities, shapes, sensitivities to share force, etc.…”