Intensification of Ester Production in a Continuous Reactor

Elgue, Sébastien; Devatine, Audrey; Prat, Laurent E.; Cognet, Patrick; Cabassud, Michel; Gourdon, Chrsitophe; Chopard, Fabrice

doi:10.2202/1542-6580.1592

Cited by 9 publications

(11 citation statements)

References 6 publications

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“…The reason for the drastic deviation in this case is that the catalyst concentration falls in another region of the preexponential factor dependency on the catalyst concentration for which parameters are not available. The model reported by Elgue et al [10] is found to deviate considerably both with respect to the equilibrium conversion as well as the rate at which it is approached. In all the cases except for 35…”

Section: Figure 12mentioning

confidence: 84%

“…However, the latter part of the profile is found to deviate considerably in this case also. The model reported by Bonnaillie et al [14] (as cited by Elgue et al [10]) is found to be slightly faster than that reported by Elgue et al [10] but is still unable to match the speed of response of the conversion of the experimental data. However, the equilibrium conversion in this case is found to match reasonably well with the experimental data.…”

Section: Figure 12mentioning

confidence: 86%

“…Engell and Fernholz [7] and Kreul et al [8] have modified the model proposed by Agreda et al [6] for application using a heterogeneous sulfonic acid ion exchange resin as the catalyst. More recently, Liu et al [9] developed a rate expression for this reaction using homogeneous sulfuric acid catalyst by considering linear dependence of the catalyst concentration on the reaction kinetics, and Elgue et al [10] have proposed a similar dependence and applied it for intensification of ester production in a continuous reactor.…”

Section: Introductionmentioning

confidence: 99%

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Development of kinetic models for acid‐catalyzed methyl acetate formation reaction: Effect of catalyst concentration and water inhibition

Ganesh

Rani

Satyavathi

et al. 2011

Int J of Chemical Kinetics

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The reaction kinetics of reversible liquid-phase esterification of acetic acid with methanol is investigated in the temperature range 26-50 • C using sulfuric acid catalyst. The main goal of this work is to study the effect of catalyst concentration and sensitivity to the presence of water on the rate expression of this industrially important reaction. Experiments are conducted in an isothermal batch reactor and a second-order kinetic model is used to correlate the experimental data, which are found to fit well with the assumed kinetic model in terms of the concentrations of reactants and products. Furthermore, an activity-based kinetic model is also developed employing the UNIQUAC (universal quasi-chemical equation) model to compute the activities. It is observed that the rate constant is influenced by the concentration of catalyst, and the reaction rate increased with an increase in the catalyst concentration. It is also observed that the catalyst activity is slightly inhibited by the water present in the reaction mixture. The performance of the proposed models is compared with that of other models reported in the literature, and it is found that the proposed models outperformed all the other models reported in the literature. C

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Section: Figure 12mentioning

confidence: 84%

Section: Figure 12mentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Development of kinetic models for acid‐catalyzed methyl acetate formation reaction: Effect of catalyst concentration and water inhibition

Ganesh

Rani

Satyavathi

et al. 2011

Int J of Chemical Kinetics

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“…A rate expression for the esterification reaction using a homogeneous sulfuric acid catalyst developed, by accounting the linear dependence of the catalyst concentration on the reaction kinetics. Elugu et al proposed a similar dependence and applied it for the intensification of ester production in a continuous reactor. The kinetic models for acid‐catalyzed methyl acetate production using a homogeneous catalyst in the batch reactor were investigated .…”

Section: Introductionmentioning

confidence: 99%

Comparative kinetics of esterification of methanol–acetic acid in the presence of liquid and solid catalysts

Mekala

Goli

2014

Asia-Pacific J Chem Eng

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Esterification of acetic acid with methanol to produce methyl acetate in an isothermal stirred batch reactor has been studied. Sulfuric acid was used as a liquid catalyst, and Indion-180, Indion-190 and Amberlyst-16wet ion exchange resins were used as solid catalysts. The feed mole ratio was varied from 1 : 1 to 1 : 4. The reaction temperatures were varied from 305.15 to 333.15 K for sulfuric acid as catalyst and 323.15 to 353.15 K for the solid catalysts. The catalyst concentrations were used in the range of 1% to 5%, for the sulfuric acid catalyst, and 0.01 to 0.05 g/cc, for the solid catalysts. The effect of temperature, catalyst concentration, agitation speed, size of catalyst particle and reactant concentration on the acetic acid conversion was investigated. A second-order kinetic rate equation was proposed to fit the experimental data. For both forward and backward reactions, the activation energies were estimated from Arrhenius plots. The reaction rate increased with catalyst concentration and temperature for both the liquid and solid catalysts. The acetic acid conversion was found to increase with increases in acetic acid to methanol ratio in the feed. The developed kinetic rate equation was used for the simulation of reactive distillation process, in our laboratory column.

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“…A complete implementation of an intensified system often requires an important amount of information on the system, including physicochemical parameters, thermokinetic models, and thermal and mixing characterization of the reactors used [12,13]. The global objective of this paper is to focus on a batch to continuous transposition of the synthesis of a urea under industrial constraints.…”

Section: Introduction Context and Objectivesmentioning

confidence: 99%

Transposition of a triphosgene-based process for pharmaceutical development: from mg·h-1 to kg·h-1 of an unsymmetrical urea

Leroyer¹,

Prat²,

Cabassud³

et al. 2013

Green Processing and Synthesis

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A two reaction synthesis of a urea, using triphosgene, was studied. The objective was to transpose the process from laboratory scale to pre-industrial plant. The whole study was performed in a continuous process, adapting the characteristic dimensions and length of the reactor. In this paper, the development of the process is presented, and the choices about safety and operating conditions constraints are discussed. The final operation allows a 70% global yield in a 7 week study. Furthermore, the use of microreactors not only permits an exhaustive study of the process operating parameters, but also provides feedback on the developed chemistry itself. The results obtained are a demonstration of the use of continuous processes in small scale reactors for complex molecule development. The mg · h -1 to kg · h -1 is a key transposition in the pharmaceutical industries project development, as it can help to accelerate the first lot production used in toxicological or pre-clinic stages.

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Intensification of Ester Production in a Continuous Reactor

Abstract: OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 4202To link to this article :

Cited by 9 publications

References 6 publications

Development of kinetic models for acid‐catalyzed methyl acetate formation reaction: Effect of catalyst concentration and water inhibition

Development of kinetic models for acid‐catalyzed methyl acetate formation reaction: Effect of catalyst concentration and water inhibition

Comparative kinetics of esterification of methanol–acetic acid in the presence of liquid and solid catalysts

Transposition of a triphosgene-based process for pharmaceutical development: from mg·h-1 to kg·h-1 of an unsymmetrical urea

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