Recently, geomorphometric properties of river networks and catchments have been described and applied as an efficient tool in the investigation of the landforms' response to neotectonics. Geometric parameters of the Cotovelo River catchment extracted from an Alos-Palsar digital elevation model were used to compute morphometric and geomorphic indices to investigate whether the bedrock structure and recent active tectonics influence the local drainage network. The Cotovelo catchment is situated in the Middle to Upper Proterozoic western foreland basin of the São Francisco craton, in northwestern Minas Gerais, Southeastern Brazil; it is presumed to be a stable piece of earth’s crust. The automatically generated streams were processed at the sub-catchment scale to calculate the hypsometric integral, relief ratio, stream frequency, and drainage density morphometric indices as well as supported a geomorphic study based on the basin shape, asymmetry factor, valley floor width-to-height ratio, mountain front sinuosity, transverse topographic symmetry factor, and stream-length gradient index. Achieved results revealed recent and low-rate tectonic activity and structural control on the fluvial morphology. Prominent knickpoints, aligned with mapped fault scarps, disclose straight erosive fronts away from stratigraphic borders, indicating these features are unrelated to lithological changes. Despite the catchment location, the area exhibits impressive fluvial anomalies, and dissection occurs preferentially along ancient faults and fractures densely occurring in the rocky strata. Channel parallelism in context of medium to high relief and steep slopes, remarkably structurally drive fluvial dissection, asymmetric and elongated drainage catchments, and aligned landforms suggest neotectonic influence on the drainage network.