Intense pulsed light treatment and meibomian gland expression for moderate to advanced meibomian gland dysfunction

Abstract

Background:The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. Conclusions: Serial intense pulsed light therapy combined with meibomian gland expression significantly improved dry eye symptoms and clinical signs, including meibomian gland secretion quality and expressibility and ocular surface inflammation. Treatment effects were cumulative and sustained for at least six weeks after the final treatment.

Dry eye syndrome: Therapeutic challenges and future trends

“…However, Craig and Jiang, et al, when doing treatment without MGE, also reported signi icant improvement in the qualitative component of the lipid layer, TFRT, and symptomatic scores [17]. Therefore, further studies with more signi icant sample numbers are needed to evaluate isolated IPL and compared it with MGE-associated IPL [12]. Comparing the success rate obtained in the eyelids, we found greater ef icacy of treatment in the lower eyelids.…”

“…However, the irst prospective analysis article to quantify clinical improvements in signs and symptoms was that of Albietz, et al in 2017. While clinical signs improved after three sessions, symptoms only improved after six weeks of inal treatment [12]. Regardless, 85% of participants had improved subjective and objective measures of symptomatology.…”

“…However, there are tests with discreet con licting results that require adequacy. For this reason, the purpose of this topic is to highlight the positive and negative aspects that were evaluated [11][12][13]. Craig, et al reported a study of 28 patients with dry eye resulting from MGD.…”

“…Vegunta, Patel, and Shen had the same incidence of success, with 89% of cases improving on the SPEED test. This test is indicated to correlate the evaporative dry eye parameters [2,12]. Another parameter evaluated by researchers Craig, Chen, and Turnbull was osmolarity and tear evaporation rate, but no changes were found.…”

“…Meanwhile, Toyos reported a minimal reduction in tear osmolarity after IPL [8]. Nevertheless, this data is clinically irrelevant, as it does not interfere with symptoms [12,17]. Guilloto, et al demonstrated the relationship between IPL treatment refractoriness and previous eye surgery.…”