Intense pulsed light for the treatment of lentigines in LEOPARD syndrome

Application of Intense Pulsed Light in the Treatment of Dermatologic Disease: A Systematic Review

“…Individual case reports have also shown dramatic clinical improvement of prominent lentigines associated with Peutz‐Jeghers syndrome (PJS) in a child and in 28‐year‐old woman with LEOPARD syndrome . Treatment of the PJS case required 12 sessions of small treatment areas to improve tolerability.…”

“…Post‐treatment hyper‐ and hypopigmentation were also noted as possible adverse effects of IPL. This pigmentary alteration typically responded to conservative management but in rare cases could be long lasting (up to 18 months) . Study dropout due to intolerance of side effects was rarely reported and was typically because of the use of overly aggressive treatment parameters.…”

“…One randomized right-left comparison trial, six uncontrolled open-label trials, and two case reports described the use of IPL for the treatment of solar lentigines and ephelides. [5][6][7][8][9][10][11][12][13] Studies cumulatively depicted 199 patients. The study characteristics are summarized in Table S2A.…”

LEOPARD Syndrome with PTPN11 Gene Mutation Showing Six Cardinal Symptoms of LEOPARD

“…The presence of lentigines remains an aesthetic problem, since malignant transformation of the lentigines has not been reported. Kontoes et al 12 reported successful use of intense pulsed light for the treatment of lentigines in a patient with LS. Lee et al 9 reported that alexandrite laser treatment was effective for the treatment of lentigines in a 11-year-old patient with LS.…”

Indicaciones actuales y nuevas aplicaciones de los sistemas de luz pulsada intensa

“…Otras entidades tratadas con éxito, algunas de ellas con escasos artículos publicados, son la melanosis de Riehl 27 , la mancha mongólica 28 , los lentigos solares y efélides 29---32 , la lentiginosis asociada a síndromes (LEOPARD, PeutzJeghers) 33 …”