Intense Pulsed Light Applied Directly on Eyelids Combined with Meibomian Gland Expression to Treat Meibomian Gland Dysfunction

Abstract

IPL combined with MGX safely and effectively treated MGD.

The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction

“…The clinical safety and tolerability of IPL therapy have been confirmed by numerous clinical studies which report no major adverse events following IPL therapy [14,16,[19][20][21][22][23][24][25][26][27][28]. However, minor or transient side effects, including mild pain, light sensitivity, eyelash loss, eyelid erythema, crusting, hyperpigmentation, and blistering have been described [12,[29][30][31].…”

Dry eye syndrome: Therapeutic challenges and future trends

“…The lack of collagen ibers causes a reduction in meibomian pumping, leading to a decrease in TRFL (tear ilm rupture time). From photomodulation, there is stimulation of ibroblast proliferation and increased collagen concentration in the skin, increasing the pressure required on the eyelid margin and normalizing glandular drainage [5][6][7]13]. Demodex is a type of ectoparasite present in the sebaceous and meibomian glands.…”

“…Demodex is a type of ectoparasite present in the sebaceous and meibomian glands. Its proliferation causes the increase of bacteria in the eyelid region, among them, Bacillus oleronius [6][7][8]. This bacterium elicits a chronic in lammatory response and acts locally through the production of toxic substances that modify the tear lipid layer [7,14].…”

“…Meibomian gland dysfunction (MGD) is the primary cause of evaporative dry eye and contributes to the development of the aqueous subtype. Glandular dysfunction generates tear ilm instability, resulting from hyperkeratinization and obstruction of external gland ori ices with abnormal production of the lipid layer in qualitative and quantitative terms [4][5][6]. The meibomian glands (acinar-tarsal) are modi ied sebaceous follicles present in the upper and lower eyelids.…”

“…In dysfunction, the organs became narrow, with atrophy of hyperkeratinized acini and increased the viscosity of the meibum, which reduces glandular low and stimulates bacterial proliferation. Under these conditions, patients present increased tear evaporation with altered osmolarity, greater susceptibility to ocular surface in lammation, epithelial damage, and discomfort [2,6]. It is clinically manifested through dryness, irritation, foreign body sensation, burning, excessive tearing, redness, itching, fatigue, recurrent infections, and transient visual disturbances [4].…”