Intense FDG Activity in Focal Hepatic Steatosis

Le, Yali; Chen, Yue; Huang, Zhanwen; Cai, Liang; Zhang, Li

doi:10.1097/rlu.0000000000000472

Cited by 9 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most important phrase that one could derive from this data could be elaborated as, FDG uptake increased in NASH and FDG SUVmax has been detected statistically significantly higher in the group with higher NAFLD scores compared to the group with lower NAFLD scores. FDG uptake may be increased as a result of irreversible FDG accumulation in inflammatory cells, suggesting that FDG PET could be developed as a potential imaging approach to NASH (24,25).…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?

Altuntuzcu

Güzel

Uyar

et al. 2021

Journal of Health Sciences and Medicine

View full text Add to dashboard Cite

Aim: Non-alcoholic fatty liver disease is one of the most common causes of liver disease worldwide with an estimated prevalence of 20%–30% in adult population. Following the widespread utilization of PET in the evaluation of malignant diseases, F-18 FDG have also been reported to be used in non-malignant processes. The aim of this study is to elucidate whether the FDG SUVmax values determined by PET/CT in different adipose tissue samples and the liver change according to NAFLD score. During our desktop research we did not find any published article therefore, it is the first study in this field. Materials and Method: A total of 230 patients who applied to Dicle University Faculty of Medicine, Department of Nuclear Medicine between March and April 2020 and who have been conducted FDG PET/CT for diagnosis, staging, restaging and evaluation of response to treatment were included in the study. Patients were divided into three groups according to their NAFLD score as patients with fibrosis score 0.676 (severe fibrosis group) group-3. Results: Liver SUVmax levels were found to be significantly higher in group-3 than group-1. No significant difference was observed between group-2 and group-3. SUVmax levels measured from supracalvicular region, posterior scapular region and mesentery region were not different from each other in all three groups. Glucose-corrected liver SUVglu levels were found to be significantly lower in group-1 than group-3 (p=0.001). In terms of liver SUVglu levels, group-1 and group-2 and group-2 and group-3 did not differ statistically from each other. Supracalvicular SUVglu, posterior scapular SUVglu and mesenteric SUVglu groups were not different from each other. Conclusions: The most important result of this study could be elaborated with increased FDG uptake in NAFLD. Liver FDG uptake increases as the severity of NAFLD increases as demonstrated by the NAFLD score.

show abstract

Section: Discussionmentioning

confidence: 99%

Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?

Altuntuzcu

Güzel

Uyar

et al. 2021

Journal of Health Sciences and Medicine

View full text Add to dashboard Cite

show abstract

“…Increased FDG uptake in the liver with high fat content could be accounted for the increased activity of Kupffer cells, a kind of macrophage that acts by engulfing FDG (23). This accumulation of FDG uptake at focal hepatic steatosis can cause a diagnostic dilemma in imaging by mimicking metastasis (24,25). Conversely, focal fat spared area in a liver with diffuse fatty infiltration can demonstrate focal FDG uptake masquerading as liver metastases, probably when steatosis is not accompanied with inflammation (26,27) In our study, we found a statistically significant difference between the body weight (p<0.001), serum ALT levels (0.025), DM status (0.002), and glucose levels (p<0.001) of the patients with fatty liver and the control group.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Effect of Fatty Infiltration on Hepatic FDG Uptake

Özülker¹,

Özülker²

2019

eamr

View full text Add to dashboard Cite

In fluorodeoxyglucose (FDG) positron emission tomography (PET)/computerized tomography (CT) studies, physiological liver FDG uptake has been used as a reference in the evaluation of FDG uptake in pathological processes, even in malignancies. There is an ongoing debate on the effect of liver attenuation and FDG uptake in the liver. We aimed to evaluate the possible effect of fatty infiltration on the standardized uptake value (SUV) of the liver. Methods: A total of 88 patients were included in this study. Subjects were divided into 2 groups by calculating the Hounsfield unit (HU) of the liver from the unenhanced CT part of the PET/CT study and comparing it with that of the spleen. Fatty liver group included 42 patients (26 female, 16 male) with a mean age of 59.6±11.6 years, while control group consisted of 46 patients (22 female, 24 male) with a mean age of 60.2±11 years. The patients with a mean liver attenuation value (in HU) equal and greater than that of spleen were enrolled in the control group, while the patients with a mean liver attenuation value lower than the spleen were included in the fatty liver group. A subset of patients in the fatty liver group with difference in attenuation between the liver and spleen of more than 10 HU (HUS-HUL >10) were evaluated separately. Age, weight, history of diabetes mellitus (DM) and chemotherapy, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, simultaneous blood glucose levels during PET scan and the elapsed time between FDG injection and the beginning of PET scan were recorded. Results: The average SUVmean and SUVmax values were 2.7±0.7 and 3.6±0.9 in the fatty liver group, 2.8±0.7 and 3.8±1 in the HUS-HUL >10 group and 3.3±0.6 and 4.4±0.9 in the control group, respectively. The average SUVmean and SUVmax values of the fatty liver group and HUS-HUL >10 group were significantly different from the control group (p<0.05). The patients in the fatty liver group had higher ALT (p=0.025) and glucose levels (p=0.001), weight (p=0.001), and DM rate (p=0.002) compared to the control group. Conclusion: Hepatic steatosis causes a statistically significant decrease in SUVmean and SUVmax values in liver. Therefore, we must be careful when using the liver as an internal reference organ

show abstract

Imaging patterns and focal lesions in fatty liver: a pictorial review

et al. 2016

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease is the most common cause of chronic liver disease and affects nearly one-third of US population. With the increasing trend of obesity in the population, associated fatty change in the liver will be a common feature observed in imaging studies. Fatty liver causes changes in liver parenchyma appearance on imaging modalities including ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) and may affect the imaging characteristics of focal liver lesions (FLLs). The imaging characteristics of FLLs were classically described in a non-fatty liver. In addition, focal fatty change and focal fat sparing may also simulate FLLs. Knowledge of characteristic patterns of fatty change in the liver (diffuse, geographical, focal, subcapsular, and perivascular) and their impact on the detection and characterization of FLL is therefore important. In general, fatty change may improve detection of FLLs on MRI using fat suppression sequences, but may reduce sensitivity on a single-phase (portal venous) CT and conventional ultrasound. In patients with fatty liver, MRI is generally superior to ultrasound and CT for detection and characterization of FLL. In this pictorial essay, we describe the imaging patterns of fatty change in the liver and its effect on detection and characterization of FLLs on ultrasound, CT, MRI, and PET.

show abstract

Intense FDG Activity in Focal Hepatic Steatosis

Cited by 9 publications

References 23 publications

Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?

Is there a relationship between the liver SUVmax values in FDG-PET/CT imaging and non-alcoholic fatty liver disease score?

Assessment of the Effect of Fatty Infiltration on Hepatic FDG Uptake

Imaging patterns and focal lesions in fatty liver: a pictorial review

Contact Info

Product

Resources

About