Government procurement is an important link in promoting the operation and development of universities, which contains a series of risks. In the era of information technology, new types of risk vulnerabilities require advanced means and prevention. This article analyzes the risks of university government procurement from key aspects such as procurement document preparation, review process, and performance acceptance, forms a risk list, and establishes a process optimization matrix. It proposes response and prevention measures for university government procurement risks in the information age, in order to provide reference and reference for university government procurement work.