Intelligent routes to the controlled synthesis of nanoparticles

Krishnadasan, Siva H.; Brown, Richard; deMello, Andrew J.; deMello, John C.

doi:10.1039/b711412e

Cited by 282 publications

(263 citation statements)

References 47 publications

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“…[39] Since then, various nanoparticles such as metal, [173] metal oxide, [174] semiconductors, [175] organic, [176] inorganic, etc., have been synthesized in MF systems, for example CdSe, Cds, Ti 2 O, boehmite, Au, Co, Ag, Pd, Cu, BaSO 4 , and CdSe − ZnS core-shell nanoparticles. [177] In nearly all cases MF synthesis has demonstrated clear advantages over conventional batch methods in terms of monodispersity and shape control. [178] MF systems offer a versatile range of advantages over fabrication of nanoparticles due to the manipulation and controlling fluid that are geometrically constrained within environments having internal dimensions on a scale of micrometers.…”

Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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“…17 In particular, pressure could be screened as a new critical parameter for high-temperature nanoparticle synthesis.…”

Section: Microfabrication and Experimental Setupmentioning

confidence: 99%

High-Pressure/High-Temperature Microreactors for Nanostructure Synthesis

Marre

Park

Bawendi

et al. 2009

JALA: Journal of the Association for Laboratory Automation

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C hemically synthesized nanomaterials, such as nanocrystalline quantum dots, are being considered as the active element in many applications, including photovoltaics, displays, and biochem sensing. To realize the promise of these devices, it will be critical to have an efficient, reproducible synthesis technique of the nanostructures. Currently, nanoparticles are synthesized in a batch mode in small volumes, which is appropriate for studying the fundamental properties of nanosized structures and for developing proof of principle device structures. However, batch synthesis suffers from control of size, size distribution, and quality of the nanomaterial from batch to batch. Moreover, there is an inherent difficulty in scaling up to quantities more reasonable for device development and optimization. Continuous-flow reactors based on microfluidics (microreactors) integrated with heaters and fluid control elements offer a solution to these problems and additional advantages. We describe continuous synthesis of nanostructures in microfluidic systems consisting of multiple subemillimeter-sized channels in which fluid flows continuously and chemical reactions take place. The small reaction volumes combined with the high heat and mass transfer rates enable reactions to be performed under more controlled conditions with higher yields than can typically be achieved with conventional reactors. Moreover, manipulation of reaction parameters, while the reaction proceeds, allows optimization of synthesis conditions. The ability to work at elevated temperatures and pressures while confining potentially toxic, high reactive starting materials will become important for the synthesis of novel nanostructured materials.

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“…For example, Krishna dasan et al [8] produced nanoparticles with a microreactor system. The flow rates and temperature were controlled by an automated computer system using the Stable Noisy Optimization by Branch and Fit (SNOBFIT) algorithm with an online fluorimeter to determine the optimal performance of nanoparticles produced [9].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Self-Optimisation Targets on the Methylation of Alcohols Using Dimethyl Carbonate in Supercritical CO2

Jumbam¹,

Skilton²,

Parrott³

et al. 2012

J Flow Chem

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This paper describes the next stage in our development of self-optimising reactors. We demonstrate that the same reaction can be optimised for a series of different criteria including yield, space-time yield, E factor and a weighted yield function (the product of space-time yield and yield). In different experiments, we achieved 97.6% yield, space-time yield of 42.9 kg/L/h and E factors of 1.4 and 3.3 (including CO 2 ) and the weighted yield, which gave a promising balance between yield, E factor and space-time yield.

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Intelligent routes to the controlled synthesis of nanoparticles

Cited by 282 publications

References 47 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

High-Pressure/High-Temperature Microreactors for Nanostructure Synthesis

The Effect of Self-Optimisation Targets on the Methylation of Alcohols Using Dimethyl Carbonate in Supercritical CO2

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