Intelligent Mobile Lab for Metabolics in Environmental Monitoring

Wiest, J.; Stadthagen, T.; Schmidhuber, Michael; Brischwein, M.; Ressler, J.; Raeder, Uta; Grothe, H.; Melzer, Arnulf; Wolf, Bernhard

doi:10.1080/00032710600714089

Cited by 45 publications

(18 citation statements)

References 14 publications

(12 reference statements)

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“…Figure 3 shows an example where the photosysnthetic activity of algae is inhibited during the presence of the xenobiotic Metamitron [16]. Recent experiments were performed on the algae chlorella kessleri with samples from Indonesian palm oil [17].…”

Section: Resultsmentioning

confidence: 99%

Methods and applications of label-free cell-based systems

Wiest¹

2016

KEG

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Label-free monitoring of living cells is used in various applications such as drug development, toxicology, regenerative medicine or environmental monitoring. The most prominent methods for monitoring the extracellular acidification, oxygen consumption, electrophysiological activity and morphological changes of living cells are described. Furthermore, the intelligent mobile lab (IMOLA) -a computer controlled system integrating cell monitoring and automated cell cultivation -is described as an example of a cell-based system for microphysiometry. Results from experiments in the field of environmental monitoring using algae are presented. An outlook toward the development of an organ-on-chip technology is given.

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Section: Resultsmentioning

confidence: 99%

Methods and applications of label-free cell-based systems

Wiest¹

2016

KEG

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“…The measurement platform has proven its successful operation in a laboratory environment [5]. The intention is to transfer this principle using yeasts cells as signal transducers.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…These living cells are a signal converter for detecting the condition of the surrounding micro milieu. The setup of the sensor technology used in this mobile device was previously described [5].…”

Section: Introductionmentioning

confidence: 99%

Development of a multiparametric handheld biosensor for use in mobile applications

et al. 2009

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Assays entirely based on cells often require large stationary devices for the use in a laboratory environment. As cells are very sensitive the impact of various agents and compounds can be observed. The potential to understand the dynamics of cellular processes justified the development of Lab-on-a-ChipSystems which allow measurement of the cellular activity in real time. Cells work as signal transducers. The handheld device introduced herein is able to collect the data of the metabolism in the cells micro milieu. Extracellular acidification (pH), oxygen consumption (pO 2 ) as well as morphology (impedance, for adherent cell lines) can be monitored online. For Point of Care operation the presented Micro-Lab (µLa) uses yeast cells for testing for harmful agents or compounds. This paper describes the technological background of the biosensor system together with its sensor technology. The set-up of cell experiments is described. The concept of an energy-saving microfluidic system is provided as well as data interpretation algorithms and measurement results are presented.

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“…The cellular acidification rate converts into a change in pH and the cellular respiration into the level of dissolved oxygen [4]. As previously shown the IMOLA can be used for drug development and research with animal cells [5], as well as for environmental monitoring with algae [6]. The IMOLA is especially suitable for environmental monitoring, since an optional GSM module can be implemented.…”

Section: Introductionmentioning

confidence: 99%

Mobile biosensor for water quality monitoring

Staudacher¹,

Schmidhuber

Wolf

et al. 2011

IEEE Africon '11

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Monitoring and maintaining the quality of water is important since it is one of the most important resources and the basis of all life. However, current methods are stationary or obsolete. The IMOLA system is able to measure the vitality of living cells online, marker free and in real time through a multiparametric microsensor chip. In combination with green algae as signal transducers it was elucidated how an emulsion of oil in water affects the vitality of the algae. It was shown that the system using the green algae Parachlorella kessleri as biosensor unit is suitable for mobile, online-detection of changes in water quality.

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Intelligent Mobile Lab for Metabolics in Environmental Monitoring

Cited by 45 publications

References 14 publications

Methods and applications of label-free cell-based systems

Methods and applications of label-free cell-based systems

Development of a multiparametric handheld biosensor for use in mobile applications

Mobile biosensor for water quality monitoring

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