Intelligent Identification of Cerebrospinal Fluid for the Diagnosis of Parkinson’s Disease

Abstract

Cerebrospinal fluid (CSF) biomarkers are more sensitive than the Movement Disorder Society (MDS) criteria for detecting prodromal Parkinson's disease (PD). Early detection of PD provides the best chance for successful implementation of diseasemodifying treatments, making it crucial to effectively identify CSF extracted from PD patients or normal individuals. In this study, an intelligent sensor array was built by using three metal−organic frameworks (MOFs) that exhibited varying catalytic kinetics after reacting with potential protein markers. Machine learning algorithms were used to process fingerprint response patterns, allowing for qualitative and quantitative assessment of the proteins. The results were robust and capable of discriminating between PD and non-PD patients via CSF detection. The k-nearest neighbor regression algorithm was used to predict MDS scores with a minimum mean square error of 38.88. The intelligent MOF sensor array is expected to promote the detection of CSF biomarkers due to its ability to identify multiple targets and could be used in conjunction with MDS criteria and other techniques to diagnose PD more sensitively and selectively.

Development of Optical Differential Sensing Based on Nanomaterials for Biological Analysis

“…Other metal nanoparticles, such as Fe 3 O 4 NPs, AgNPs, MoS 2 , and CuS NPs, were also prepared to develop sensor arrays for the discrimination of proteins, bacteria, and cells [78,[176][177][178][179][180][181][182][183]. Scientists fabricated dopamine and trimethylammonium functionalized Fe 3 O 4 NPs, which were able to catalyze the oxidation of colorless ABTS to become a green product in the presence of H 2 O 2 [66].…”

Autocatalytic Artesunate Coordinated ZIF-8 Nanoplatforms with Metal-Polyphenol Network Coating for Targeted Tumor Chemodynamic Therapy

“…Recently, metal–organic framework (MOF) is an emerging porous coordination framework material formed by the coordination of metal ions or metal clusters with organic ligands. − Compared with the traditional drug delivery system, MOF has broad application prospects in drug delivery due to its advantages of high porosity, large specific surface area and easy modification. − Interestingly, the coordination between bivalent metal ions and organic ligands is reversible, which can be broken under low pH condition to achieve intelligent drug release. − As a typical MOF, zeolite imidazole framework-8 (ZIF-8) is formed by the coordination of Zn 2+ with the N atom on the 2-methylimidazole (2-MIM). − Zn 2+ is essential for human body and 2-MIM is involved in histidine metabolism . These advantages endow ZIF-8 with versatile biomedical applications as an ideal drug carrier.…”