Intelligent Fe–Mn Layered Double Hydroxides Nanosheets Anchored with Upconversion Nanoparticles for Oxygen‐Elevated Synergetic Therapy and Bioimaging

Jia, Tao; Wang, Zhao; Sun, Qianqian; Dong, Seung Myung; Xu, Jiating; Zhang, Fangmei; Feng, Lili; Yang, Dan; Yang, Piaoping; Lin, Jun

doi:10.1002/smll.202001343

Cited by 89 publications

(83 citation statements)

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“…[ 127 ] In recent studies, many 2D nanomaterials, such as GO, MoS 2 , MoSe 2 , Bi 2 Se 3 , and black phosphorus, have been explored for PTT of tumors mediated by near‐infrared light (NIR). [ 128–131 ] Liu et al. first reported that 2D ultrathin MnO 2 nanosheets, as novel photothermal agents, had essentially high photothermal conversion capacity for highly efficient PTT against tumor with ultra‐sensitivity to endogenous TME.…”

Section: The Synthesis Of Mn‐based Nanostructures For Bioimaging and Cancer Therapymentioning

confidence: 99%

“…[127] In recent studies, many 2D nanomaterials, such as GO, MoS 2 , MoSe 2 , Bi 2 Se 3 , and black phosphorus, have been explored for PTT of tumors mediated by near-infrared light (NIR). [128][129][130][131] Liu et al first reported that 2D ultrathin MnO 2 nanosheets, as novel photothermal agents, had essentially high photothermal conversion capacity for highly efficient PTT against tumor with ultra-sensitivity to endogenous TME. [73] Ultra-thin 2D MnO 2 nanosheets were prepared by chemical exfoliation, which was modified with soybean phospholipid (SP) via rotary evaporation technology, resulting in high stability in physiological solution (Figure 7).…”

Section: Mno 2 Nanosheetsmentioning

confidence: 99%

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Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

Ruan

Qian

2021

Advanced Therapeutics

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Manganese‐based nanomaterials have emerged as potential and important nanomedicine for bioimaging and cancer treatment due to their excellent electronic structure and intrinsic physiochemical property and sensitivity to tumor microenvironment (TME). In this review, the recent progress on the synthesis and applications of various manganese oxides, sulfides with well‐controlled size, morphologies, chemical composition, and nanostructures have been summarized. Numerous samples have been chosen as examples to demonstrate the as‐designed Mn‐based nanostructures for their specifically responded to the TME to produce highly toxic reactive oxygen species via Fenton‐like reactions. Some advanced nanotechnology has been widely used to enhance their therapeutic performance on the cancer treatment under external physical field for multimodal imaging and cancer therapy including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, radiation therapy, starving therapy, and gas therapy. Perspectives have been presented to demonstrate in this cutting‐edge research area.

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Section: The Synthesis Of Mn‐based Nanostructures For Bioimaging and Cancer Therapymentioning

confidence: 99%

Section: Mno 2 Nanosheetsmentioning

confidence: 99%

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

Ruan

Qian

2021

Advanced Therapeutics

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“…As an unusual anti-stokes process, photon upconversion (UC) refers to converting several low-energy photons to one high-energy photon ( Zhou et al, 2015 ; Wei et al, 2016 ). Due to the non-linear instincts, UC materials are well-developed for bio-imaging ( Gonzalez-Bejar et al, 2016 ; Chen et al, 2021 ), photo-dynamics therapy( Lucky et al, 2015 ; Liu et al, 2019 ; Jia et al, 2020 ), and single particle imaging ( Gargas et al, 2014 ; Liu et al, 2017 ; Zhou et al, 2020b ; Dong et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

Feng

Zheng

et al. 2021

Front. Chem.

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The availability of colloidal nano-materials with high efficiency, stability, and non-toxicity in the near infrared-II range is beneficial for biological diagnosis and therapy. Rare earth doped nanoparticles are ideal luminescent agents for bio-applications in the near infrared-II range due to the abundant energy level distribution. Among them, both excitation and emission range of Er3+ ions can be tuned into second biological window range. Herein, we report the synthesis of ∼15 nm LiYF4, NaYF4, and NaGdF4 nanoparticles doped with Er3+ ions and their core-shell structures. The luminescent properties are compared, showing that Er3+ ions with single-doped LiYF4 and NaYF4 nanoparticles generate stronger luminescence than Er3+ ions with doped NaGdF4, despite the difference in relative intensity at different regions. By epitaxial growth an inert homogeneous protective layer, the surface luminescence of the core-shell structure is further enhanced by about 5.1 times, 6.5 times, and 167.7 times for LiYF4, NaYF4, and NaGdF4, respectively. The excellent luminescence in both visible and NIR range of these core-shell nanoparticles makes them potential candidate for bio-applications.

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“…Consequently, searching for integrated therapeutic strategies with multi-modal therapeutics is highly necessary to achieve remarkable antitumor effects. [8][9][10][11][12] The SDT and PDT have been selected as potential clinical methods for treating a wide range of superficial and localized tumors. They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH).…”

mentioning

confidence: 99%

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

et al. 2021

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clinical cancer treatments. [1] Though some conventional methods, such as surgery, radiotherapy, and chemotherapy, have been used to treat malignant melanoma in clinics, these methods have exhibited limited treatment efficiencies in inhibiting tumor growth, leading to low patient survival rates. Therefore, more creative and efficient ways are urgently needed to overcome these clinical bottlenecks; for instance, gene therapy, photodynamic therapy (PDT), photothermal therapy, sonodynamic therapy (SDT), and immunotherapy. [2][3][4][5][6] However, due to the diversity, complexity, and heterogeneity of the MM tumor, [7] mono-modal therapy has been found to show limited treatment efficiency for MM tumors. Consequently, searching for integrated therapeutic strategies with multi-modal therapeutics is highly necessary to achieve remarkable antitumor effects. [8][9][10][11][12] The SDT and PDT have been selected as potential clinical methods for treating a wide range of superficial and localized tumors. They utilize the sono-irradiation or photoexcitation to generate highly reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and hydroxyl radicals (•OH). [13][14][15][16][17] Owing to the temporal and spatial management over the localization of the sound or light, the ROS can be generated precisely in the tumor tissues instead of normal tissue, thus minimizing the side effects. [18][19][20] The unique quantity of deep tissue penetration and little side The diversity, complexity, and heterogeneity of malignant tumor seriously undermine the efficiency of mono-modal treatment. Recently, multi-modal therapeutics with enhanced antitumor efficiencies have attracted increasing attention. However, designing a nanotherapeutic platform with uniform morphology in nanoscale that integrates with efficient chem-/sono-/phototrimodal tumor therapies is still a great challenge. Here, new and facile Pd-single-atom coordinated porphyrin-based polymeric networks as biocatalysts, namely, Pd-Pta/Por, for chem-/sono-/photo-trimodal tumor therapies are designed. The atomic morphology and chemical structure analysis prove that the biocatalyst consists of atomic Pd-N coordination networks with a Pd-N 2 -Cl 2 catalytic center. The characterization of peroxidase-like catalytic activities displays that the Pd-Pta/Por can generate abundant •OH radicals for chemodynamic therapies. The ultrasound irradiation or laser excitation can significantly boost the catalytic production of 1 O 2 by the porphyrin-based sono-/photosensitizers to achieve combined sono-/photodynamic therapies. The superior catalytic production of •OH is further verified by density functional theory calculation. Finally, the corresponding in vitro and in vivo experiments have demonstrated their synergistic chem-/sono-/photo-trimodal antitumor efficacies. It is believed that this study provides new promising single-atom-coordinated polymeric networks with highly efficient biocatalytic sites and synergistic trimodal therapeutic effects, which may inspire many new findings in rea...

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Intelligent Fe–Mn Layered Double Hydroxides Nanosheets Anchored with Upconversion Nanoparticles for Oxygen‐Elevated Synergetic Therapy and Bioimaging

Abstract: Scheme 1. Schematic illustration for the formation and transport of UCSP-LDH in blood vessel, enhanced permeability and retention (EPR) mediated tumor accumulation, proposed PDT/PTT/CDT mechanism, and multiple imaging functions.

Cited by 89 publications

References 83 publications

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

Recent Development on Controlled Synthesis of Mn‐Based Nanostructures for Bioimaging and Cancer Therapy

NIR-II Upconversion Photoluminescence of Er3+ Doped LiYF4 and NaY(Gd)F4 Core-Shell Nanoparticles

Pd‐Single‐Atom Coordinated Biocatalysts for Chem‐/Sono‐/Photo‐Trimodal Tumor Therapies

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