Intelligent design of iron-doped LDH nanosheets for cooperative chemo-chemodynamic therapy of tumors

Zhang, Luyao; Li, Gaoming; Ouyang, Zhijun; Yang, Rui; Gao, Yue; Cao, Xueyan; Bányai, István; Shi, Xiangyang; Guo, Rui

doi:10.1039/d2bm00102k

Cited by 14 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

“…Some researchers designed Fe-doped layered double hydroxide (LDH) nanosheets to encapsulate the polyphenolic compound EGCG [ 138 ]. This nanoplatform can precisely release Fe and EGCG in the TME while causing no harm to healthy organs [ 138 ]. Ferroptosis induced by Fe and EGCG-triggered apoptosis synergistically inhibited tumor growth in melanoma animal models [ 138 ].…”

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

“…This nanoplatform can precisely release Fe and EGCG in the TME while causing no harm to healthy organs [ 138 ]. Ferroptosis induced by Fe and EGCG-triggered apoptosis synergistically inhibited tumor growth in melanoma animal models [ 138 ]. Nano-based delivery strategies make possible the combinational use of multiple functional drugs simultaneously.…”

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

See 2 more Smart Citations

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Jia

Zhou

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Polyphenols and their derivates, a kind of natural product distributed in herb plants, vegetables, and fruits, are the most abundant antioxidants in the human diet and have been found to display cancer-preventative effects in several epidemiological studies. The scientific community has also validated the anti-cancer bioactivities and low toxicities of polyphenolic compounds, including flavones, tannins, phenolic acids, and anthocyanins, through in vitro and in vivo studies. However, the low stability, weak targeting ability, poor solubility, and low bioavailability of pure polyphenolic agents have significantly impaired their treatment efficacy. Nowadays, nano-based technology has been applied to surmount these restrictions and maximize the treatment efficacy of polyphenols. In this review, we summarize the advantages and related mechanisms of polyphenols in cancer treatment. Moreover, aiming at the poor solubility and low bioavailability of pure polyphenols in vivo, the advantages of nano-based delivery systems and recent research developments are highlighted. Herein, particular emphasis is mainly placed on the most widely used nanomaterials in the delivery of natural products, including liposomes, micelles, and nanogels. Finally, we present an overview and the challenges of future implementations of nano-based delivery systems of polyphenolic compounds in the cancer therapeutic field.

show abstract

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

Section: Progress In Nanocarrier-mediated Delivery Of Polyphenolic Co...mentioning

confidence: 99%

See 1 more Smart Citation

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Jia

Zhou

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…The production of •OH is signi cant for inducing ferroptosis of tumor cells, so we rst examined the generation of •OH. The •OH can be captured by 5,5-dimethyl-1-pyrroline N-oxide (DMPO), and detected by an electron spin resonance (ESR) instrument 32 . The clear ESR signals with intensity ratio of 1:2:2:1 were observed for all samples at pH 7.4, indicating that FeOCl nanosheets can generate •OH in neutral (Fig.…”

Section: Ros Detectionmentioning

confidence: 99%

“…The OH radicals can be captured by 5,5-dimethyl-1pyrroline N-oxide (DMPO), and detected using an electron spin resonance (ESR) instrument. 32 Clear ESR signals with an Fig. 1 TEM images of FeOCl nanosheets (A) and FeOCl@PAA-Lip (B).…”

Section: Ros Detectionmentioning

confidence: 99%

Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis

Guo

Chen

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Adipose Tissue Targeting Ultra‐Small Hybrid Nanoparticles for Synergistic Photodynamic Therapy and Browning Induction in Obesity Treatment

Ma,

Jian,

Guo

et al. 2023

Small

View full text Add to dashboard Cite

Photodynamic therapy (PDT), as a means of locally and rapidly inducing adipocyte death via light illumination, in combination with adipose browning induction, a more gradual and widespread effect that could transform white adipose tissue into thermogenic adipose tissue, manifests a promising approach to combat obesity. Herein, adipose‐targeting ultra‐small hybrid nanoparticles (Pep‐PPIX‐Baic NPs) composed of an adipose‐targeting peptide, Fe3+, a photosensitizer (protoporphyrin IX), and a browning agent (baicalin) are introduced. Pep‐PPIX‐Baic NPs have been designed to simultaneously enhance the photodynamic effect and induce browning. After intravenous injection in obese mice, the hybrid nanoparticles can specifically accumulate in white adipose tissues, especially those rich in blood supply, and drive adipose reduction owing to the synergy of the PDT effect and baicalin browning induction. Overall, Pep‐PPIX‐Baic NPs exhibited superior anti‐obesity potential through PDT synergistic with adipose browning induction. The designed multifunctional adipose‐targeting hybrid nanoparticles present a prospective nanoplatform for obesity treatment.

show abstract

Intelligent design of iron-doped LDH nanosheets for cooperative chemo-chemodynamic therapy of tumors

Abstract: Chemodynamic therapy (CDT) has received increasing attention due to its unique tumor microenvironment (TME) responsiveness and minimal adverse side effects, but the therapeutic effect of CDT alone is always limited...

Cited by 14 publications

References 41 publications

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges

Unsaturated phospholipid modified FeOCl nanosheets for enhancing tumor ferroptosis

Adipose Tissue Targeting Ultra‐Small Hybrid Nanoparticles for Synergistic Photodynamic Therapy and Browning Induction in Obesity Treatment

Contact Info

Product

Resources

About