Intelligence Way from Eco-friendly Synthesis Strategy of New Heterocyclic Pyrazolic Carboxylic α-Amino Esters

The intelligence way of economical synthesis strategies of an N-alkylcarbazole

“…The carbazole nucleus can be naturally found in the composition of some alkaloids as staurosporine, ellipticine or koenidine, with antibacterial, antifungal, antimalarial properties, antitumoral activity, and potential antidiabetic effect [6,7,8], among them carbazomycins represent an unprecedented class of antibiotics with a carbazole heterocycle [9]. Various researches done on the synthesis of new heterocyclic compounds [10,11,[12][13][14][15][16][17][18], we focused in this work, on the theoretical study of the reaction carried out followed by the effective synthesis of the 9-(prop-2-yn-1-yl)-9H-carbazole with three methods (phase transfer catalysis, microwave, and base + acetone) with the aim to elaborate a new active molecules with an important yield. For us, it is preferable to establish a theoretical study of a synthetic reaction before going to the experimental mode because it will inform us from the start on the path of the reaction and the expected results to save time and minimize losses of energy (use of heating or not) and matter (reaction possible or not).…”