Intelligence and handedness

Roberts, L. D.

doi:10.1038/252180c0

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The properties of this fraction are described in Tables 3 and 4. Table 3 summarizes the capabilities of different P3 subfractions to interact with characteristic ligands and compares them with a standard preparation of synaptic 'Preliminary results show that SPM and P3Bz were also enriched in the binding of C3H]atropine, ['H]~-glutamate, ['HIGABA, and C3H]dopamine under conditions designed to show mainly the specific binding of these substances to their receptors (BARTFAY et al, 1974;ROBERTS, 1974;SIMON et al, 1976;ZUKIN et al, 1974;BURT et al, 1975;SEEMAN et al, 1975). However no extensive characterization of these recepotrs has been accomplished.…”

Section: Receptor Activity Can Be Enriched By Fractionating P mentioning

confidence: 99%

Studies on Nicotinic Acetylcholine Receptors in Mammalian Brain. Characterization of a Microsomal Subfraction Enriched in Receptor Function for Different Neurotransmitters

Blas

Mahler

1978

Journal of Neurochemistry

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Abstract— A subfraction, derived from the microsomal fraction of rat cerebral cortex, with a buoyant density of 1.112 g μ ml−1 appears to be enriched in receptor sites for a number of potential neurotrans‐mitters. These include the cholinergic (nicotinic and muscarinic) and ß‐adrenergic receptors. This microsomal subfraction (P3B2) has been isolated on a preparative scale by two sequential isopycnic sedimentations in discontinuous sucrose gradients. We have studied the morphology, enzymatic markers and protein composition of this fraction and have compared them with the properties of other subcellular fractions from the same source. Synaptic plasma membranes resembled P3B2 by exhibiting the same high extent of enrichment in receptors. However, the synaptic membranes appear to contain more mitochondrial and presynaptic (axonal and cell surface) membranes than does P3B2, and the postsynaptic membranes in the two fractions appear morphologically distinct since P3B2 does not contain the characteristic postsynaptic densities. Thus these membranes may be derived from Gray's type II synapses.

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Section: Receptor Activity Can Be Enriched By Fractionating P mentioning

confidence: 99%

Studies on Nicotinic Acetylcholine Receptors in Mammalian Brain. Characterization of a Microsomal Subfraction Enriched in Receptor Function for Different Neurotransmitters

Blas

Mahler

1978

Journal of Neurochemistry

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Mathematical Ability and Lateral Asymmetry

Annett

Kilshaw

1982

Cortex

137

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The hypothesis that special ability in mathematics is associated with a reduction in bias to dextral preference and skill was examined in several samples of students and in 97 male and 27 female teachers of mathematics, mainly in Universities and Polytechnics. The math students and math teachers differed from controls, both general and academic, in the direction predicted and several comparisons were statistically significant. Differences were in most cases clearer for males than females. An analysis of the findings in relation to the right shift (RS) theory of handedness (Annett, 1972, 1978) suggests that the incidence of left preference and skill is slightly raised in mathematicians not because of any intrinsic advantage of left preference but rather because extreme bias to the right, as expected in those carrying a hypothesised rs++ genotype, is disadvantageous for mathematical thinking. If the role of mathematics can be regarded as one of developing languages to describe those aspects of human experience which otherwise could be understood only in visuo-spatial images, it can be seen to require a coordination of those aspects of human intelligence which have been distinguished as depending differentially on the left and right cerebral hemispheres. The present findings suggest that this process might be impeded by a double dose of a gene which promotes left hemisphere language specialisation.

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The Relationship Between Nonverbal Intelligence, Familial Sinistrality and Geschwind Scores in Right-Handed Female Subjects

Tan

1988

International Journal of Neuroscience

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I proposed that there might be a strong relationship between the psychological and motor systems, and argued that hand preference could be related to intelligence; higher IQs are to be expected in right-handers with familial sinistrality (FS) than without FS (Tan, in press). This hypothesis was tested in this work. Cattle's Culture Fair Intelligence Test was used to assess the ability of spatial reasoning in right-handed females. Hand preference was assessed by the Edinburgh Handedness Questionnaire; a laterality score (Geschwind score) was calculated for each subject. The sample from the Nursery High-school had a significantly lower mean IQ than that from the Medical Faculty. The incidence for the consistent right-handers was significantly higher in the sample with lower mean IQ than that with higher mean IQ. The incidence for the weak right-handers was significantly higher in the sample with higher mean IQ than that with lower mean IQ. The incidence for familial sinistrality was significantly higher in the sample with higher mean IQ than that with lower mean IQ. It was concluded that handedness, familial sinistrality, and intelligence are interrelated traits; an attenuation in cerebral asymmetry as a result of an increase in the right hemisphere's mental abilities, reflecting itself in weak right-handedness in conjunction with FS, could be a prerequisite for well-developed nonverbal intelligence.

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Intelligence and handedness

Cited by 3 publications

References 3 publications

Studies on Nicotinic Acetylcholine Receptors in Mammalian Brain. Characterization of a Microsomal Subfraction Enriched in Receptor Function for Different Neurotransmitters

Studies on Nicotinic Acetylcholine Receptors in Mammalian Brain. Characterization of a Microsomal Subfraction Enriched in Receptor Function for Different Neurotransmitters

Mathematical Ability and Lateral Asymmetry

The Relationship Between Nonverbal Intelligence, Familial Sinistrality and Geschwind Scores in Right-Handed Female Subjects

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