Intellectual impairment and TCD evaluation in children with sickle cell disease and silent stroke

Onofri, Angelo; Montanaro, Maria; Rampazzo, Patrizia; Colombatti, Raffaella; Farina, Filippo; Manara, Renzo; Sainati, Laura; Ermani, Mario; Baracchini, Claudio; Meneghetti, Giorgio

doi:10.1016/j.permed.2012.02.006

Cited by 7 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the only study to report a positive association between blood flow velocity and cognition in a Sickle cell disease sample, Kral et al [ 21 ] reported that after controlling for age and hematocrit, children with Sickle cell disease and high and mid-range systolic velocities had better verbal memory (Children’s Memory Scale Stories) compared with children with Sickle cell disease and normal TCD velocities. There were also reports of a lack of association between blood flow velocities and cognition in Sickle cell disease child samples [ 16 , 18 , 26 , 31 ]. Onofri et al [ 31 ] found no relationship between IQ (performance and verbal) and systolic velocities in a sample of children with Sickle cell disease.…”

Section: Resultsmentioning

confidence: 99%

“…There were also reports of a lack of association between blood flow velocities and cognition in Sickle cell disease child samples [ 16 , 18 , 26 , 31 ]. Onofri et al [ 31 ] found no relationship between IQ (performance and verbal) and systolic velocities in a sample of children with Sickle cell disease. A study by Aygun et al [ 16 ] observed no association between scores on an academic screening test and mean velocities (from multiple vessels).…”

Section: Resultsmentioning

confidence: 99%

“…The majority of studies reported an association between blood flow velocity and cognition, with the extremes of systolic and mean blood flow velocities (i.e., very low or very high) being associated with poorer cognitive or neurological functioning. However, six studies reported no associations, including four Sickle cell disease studies [ 16 , 18 , 26 , 31 ], one study on preterm infants [ 12 ] and one on children with sleep disordered breathing [ 7 ]. The interpretation of these studies reporting no association is limited by the lack of information about potential confounders (e.g., medication doses and age), which are required to adequately examine the outcome of cognitive performance in children by means of TCD.…”

Section: Discussionmentioning

confidence: 99%

“…Conflicting other studies, Kral et al [ 21 ] reported that after controlling for age and medication, children with Sickle cell disease and higher systolic velocities displayed better verbal memory performance than those with lower velocities. Four Sickle cell disease studies reported no association between cognitive performance and resting blood flow velocities [ 16 , 18 , 26 , 31 ]. There have been mixed findings from other brain imaging techniques in Sickle cell samples, for example poor cognitive function has been associated with decreased regional cerebral blood flow as measured using PET [ 33 ] and increased cerebral blood flow using fMRI [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cerebrovascular function and cognition in childhood: a systematic review of transcranial doppler studies

et al. 2014

View full text Add to dashboard Cite

BackgroundThe contribution of cerebrovascular function to cognitive performance is gaining increased attention. Transcranial doppler (TCD) is portable, reliable, inexpensive and extremely well tolerated by young and clinical samples. It enables measurement of blood flow velocity in major cerebral arteries at rest and during cognitive tasks.MethodsWe systematically reviewed evidence for associations between cognitive performance and cerebrovascular function in children (0-18 years), as measured using TCD. A total of 2778 articles were retrieved from PsychInfo, Pubmed, and EMBASE searches and 25 relevant articles were identified.ResultsMost studies investigated clinical groups, where decreased blood flow velocities in infants were associated with poor neurological functioning, and increased blood flow velocities in children with Sickle cell disease were typically associated with cognitive impairment and lower intelligence. Studies were also identified assessing autistic behaviour, mental retardation and sleep disordered breathing. In healthy children, the majority of studies reported cognitive processing produced lateralised changes in blood flow velocities however these physiological responses did not appear to correlate with behavioural cognitive performance.ConclusionPoor cognitive performance appears to be associated with decreased blood flow velocities in premature infants, and increased velocities in Sickle cell disease children using TCD methods. However knowledge in healthy samples is relatively limited. The technique is well tolerated by children, is portable and inexpensive. It therefore stands to make a valuable contribution to knowledge regarding the underlying functional biology of cognitive performance in childhood.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cerebrovascular function and cognition in childhood: a systematic review of transcranial doppler studies

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Currently, limited literature is available on memory function and its association with sickle cell trait [4]. Intellectual activity impairment can occur in sickle cell trait as about 25% of individuals with sickle cell trait have a significant cognitive issue [37]. In a small sample of patients with sickle trait but without clinical stroke, the incidence of mild mental loss was raised 11-fold.…”

Section: Neurocognitive Impairments In Sickle Cell Trait and Diseasementioning

confidence: 99%

A Traditional Review of Sickle Cell Disease and the Associated Onset of Dementia: Hematological and Neurocognitive Crossroads

Ojinnaka¹,

Ahmed²,

Kannan³

et al. 2021

Cureus

View full text Add to dashboard Cite

Sickle cell trait and disease are potential risk factors for dementia and cognitive dysfunction in African Americans, as are genetic variants. This illness affects around 300 million people globally. Due to its ability to defend against severe malaria, it represents an evolutionary survival advantage. It has been shown that sickle cell disease and trait are independent risk factors for the prevalence and incidence of albuminuria and chronic renal disease. Sickle cell anemia impairs cognitive performance in people with minimal or mild manifestations of the genetic blood disorder, owing mostly to its cerebrovascular implications. Similarly, various cerebral minor vascular disorders, such as silent cerebral infarcts, have been linked to the sickle cell trait, which is associated with impaired cognitive ability. It has been found that patients with sickle cell disease have a significantly decreased subcortical and cortical brain volume. Adults and children with sickle cell disease have been documented to have attention-related issues, particularly reduced sustained attention.

show abstract

The Role of Family Functioning in the Development of Executive Functions in Preschool Children with Sickle Cell Anemia

Downes

Haan

Telfer

et al. 2019

Developmental Neuropsychology

View full text Add to dashboard Cite

Intellectual impairment and TCD evaluation in children with sickle cell disease and silent stroke

Cited by 7 publications

References 15 publications

Cerebrovascular function and cognition in childhood: a systematic review of transcranial doppler studies

Cerebrovascular function and cognition in childhood: a systematic review of transcranial doppler studies

A Traditional Review of Sickle Cell Disease and the Associated Onset of Dementia: Hematological and Neurocognitive Crossroads

The Role of Family Functioning in the Development of Executive Functions in Preschool Children with Sickle Cell Anemia

Contact Info

Product

Resources

About