Intellectual and psychosocial functions of children, adolescents and young adults before and after operation for craniopharyngioma

Galatzer, Avinoam; Nofar, E.; Beit-Halachmi, N; Aran, Ofra; Shalit, M. N.; Roitman, A.; Laron, Zvi

doi:10.1111/j.1365-2214.1981.tb00848.x

Cited by 42 publications

(25 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Craniopharyngioma resection may cause hormonal deficiencies and vision impairment related to the location of the tumor. In the follow up of these children, there are reports of morbid obesity and alterations in complex cortex functions, such as memory and behavior, as well as learning disabilities [9][10][11] . The combination of these conditions severely compromises the quality of life of these children.…”

Section: Discussionmentioning

confidence: 99%

Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon

Dastoli

Nicácio

Silva

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective: To assess whether the cystic craniopharyngiomas can be controlled with the use of intratumoral applications of interferon alpha. Method: Nineteen patients with the diagnosis of cystic craniopharyngioma were treated with intratumoral chemotherapy with interferon alpha from January 2002 to April 2006. All patients underwent placement of an intracystic catheter connected to an Ommaya reservoir. Through this reservoir were made applications during chemotherapy cycles. Each cycle corresponded to application of 3,000,000 units of interferon alpha three times per week on alternate days totalizing 36,000,000 units. Response to treatment was evaluated by calculating the tumor volume on MRI control after one, three and six months after the end of each cycle. Patients who developed worsening of symptoms or who had insignificant reduction in tumor volume during follow-up underwent repeat cycle chemotherapy. Results: Four patients received four cycles of chemotherapy, three patients received three cycles, six patients received two cycles and six patients received one. The lower percentage of reduction in tumor volume was 60% and the bigger reduction was 98.37%. Eleven patients had a reduction greater than 90%. Five patients had a tumor reduction between 75 and 90% and in three patients the tumors were reduced by less than 75%. No deaths occurred during treatment and side effects of interferon alpha were well tolerated. No treatment was discontinued. Follow-up after the last application ranged from one year and five months to three years and nine months. Conclusion: The intratumoral chemotherapy with interferon alpha decreases the volume of cystic craniopharyngiomas and so far can be considered a new therapeutic alternative.

show abstract

Section: Discussionmentioning

confidence: 99%

Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon

Dastoli

Nicácio

Silva

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…After surgery, hyperphagia and obesity occur on average in about 50% of all CP patients [11,12,13], although study results vary from 6% [14] to 91% [10,15], with higher rates in CP patients with hypothalamic damage compared to CP without hypothalamic damage. In children and adolescents, the incidence of severe obesity following CP resection surgery is between 22% and 62% [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity?

Roth¹,

Aylward²,

Liang

et al. 2012

Obes Facts

View full text Add to dashboard Cite

Objective: To use functional magnetic resonance imaging (fMRI) in craniopharyngioma (CP) patients to examine the hypothesis that hypothalamic damage due to CP and its treatment results in enhanced perception of food reward and/or impaired central satiety processing. Methods: Pre- and post-meal responses to visual food cues in brain regions of interest (ROI; bilateral nucleus accumbens, bilateral insula, and medial orbitofrontal cortex) were assessed in 4 CP patients versus 4 age- and weight-matched controls. Stimuli consisted of images of high- (‘fattening’) and low-calorie (‘non-fattening’) foods in blocks, alternating with non-food object blocks. After the first fMRI scan, subjects drank a high-calorie test meal to suppress appetite, then completed a second fMRI scan. Within each ROI, we calculated mean z-scores for activation by fattening as compared to non-fattening food images. Results: Following the test meal, controls showed suppression of activation by food cues while CP patients showed trends towards higher activation. Conclusion: These data, albeit in a small group of patients, support our hypothesis that perception of food cues may be altered in hypothalamic obesity (HO), especially after eating, i.e. in the satiated state. The fMRI approach is encouraging for performing future mechanistic studies of the brain response to food cues and satiety in patients with hypothalamic or other forms of childhood obesity.

show abstract

“…The prevalence varies from 6% [6] to 91 % [7], Hyperphagia is commonly reported [4,5,8,9] but the extreme nature that this symptom may assume and the adverse effects on social adjustment that may derive from the associated behavioral pathology have received little or no attention in the English literature. All 3 of our patients showed abnormal food-seeking behavior including the stealing of food and stealing money for food.…”

Section: Discussionmentioning

confidence: 99%

“…The need for special schooling because of deficiencies in cognitive function and scholastic performance in post operative craniopharyngioma patients has been reported [6,9,20,23,24] though overall IQ remains more or less at the preoperative level. Emotional lability [20,21], changes in sleep/wake pattern [21,25], and hyposexuality [23] have also been noted.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Skórzewska¹,

Lal²,

Waserman³

et al. 1989

Neuropsychobiology

View full text Add to dashboard Cite

Three patients are described in whom surgical removal of a craniopharyngioma was followed by extreme hyperphagia resulting in obesity and abnormal food-seeking behavior, including foraging for food, stealing food or stealing money for food. These behaviors resemble those seen in the Prader-Willi syndrome but contrast with those noted in bulimia. This deviant behavior was a major factor in the poor outcome of surgery. Attempts at rehabilitation were unsuccessful.

show abstract

Intellectual and psychosocial functions of children, adolescents and young adults before and after operation for craniopharyngioma

Cited by 42 publications

References 6 publications

Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon

Cystic craniopharyngioma: intratumoral chemotherapy with alpha interferon

Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity?

Abnormal Food-Seeking Behavior after Surgery for Craniopharyngioma

Contact Info

Product

Resources

About