Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis

Abstract

Background: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population.Objective: To compare COVID-19 trends among people with and without IDD, overall and stratified by age. Methods: Data from the TriNetX COVID-19 Research Network platform was used to identify COVID-19 patients. Analysis focused on trends in comorbidities, number of cases, number of deaths, and casefatality rate among patients with and without IDD who had a positive diagnosis for COVID-19 through May 14, 2020. Results: People with IDD had higher prevalence of specific comorbidities associated with poorer COVID-19 outcomes. Distinct age-related differences in COVID-19 trends were present among those with IDD, with a higher concentration of COVID-19 cases at younger ages. In addition, while the overall casefatality rate was similar for those with IDD (5.1%) and without IDD (5.4%), these rates differed by age: ages 17 e IDD 1.6%, without IDD <0.01%; ages 18e74 e IDD 4.5%, without IDD 2.7%; ages 75e IDD 21.1%, without IDD, 20.7%. Conclusions: Though of concern for all individuals, COVID-19 appears to present a greater risk to people with IDD, especially at younger ages. Future research should seek to document COVID-19 trends among people with IDD, with particular attention to age related trends.

Impact of COVID-19 on people with physical disabilities: A rapid review

“…However, impacts experienced by people with intellectual and developmental disabilities should also be considered and assessed in future reviews, as they are also considered as a population vulnerable to negative outcomes during this crisis. 59 , 60 , 61 Another limitation of this review is the lengthy publishing process of some journals, which might result in a lack of studies about the impact of COVID-19 on people with physical disabilities in the short term. Indeed, some medical journals have accelerated their publishing process for studies about COVID-19, but it does not seem to be the case for all rehabilitation journals, which generally publish studies about people with physical disabilities.…”

Coronavirus Disease 2019 in Patients With Prior Ischemic Stroke

“…However, the TriNetX platform allows analysis in the form of queries. The TriNetX platform has previously been described in detail in several similar studies on COVID-19 that used this platform [3,8,9,10,11]. At University of Arkansas for Medical Sciences, the data from TriNetX is managed by the Arkansas Clinical Data Repository (AR-CDR) and maintained by the Department of Biomedical Informatics.…”

Coping, fostering resilience, and driving care innovation for autistic people and their families during the COVID-19 pandemic and beyond

“…An early analysis of globally federated electronic medical record data (through May 14, 2020) shows that individuals with intellectual and developmental disabilities (IDD, including autism) have higher prevalence of specific physical comorbidities associated with poorer COVID-19 outcomes. Furthermore, among younger people (≤ 17 years), those with IDD are more likely to be infected and experience higher fatality rate than those without IDD [6]. Within days of the World Health Organization declaring the pandemic, physical distancing measures were implemented, leading to the closure of schools and businesses, transition to work-from-home when possible, massive job loss, and economic uncertainty.…”

“…Autistic individuals and their families can be particularly impacted by the COVID-19 pandemic and the sequelae [9][10][11], especially those with intellectual disability or with high support needs [6,12,13]. For example, only 25% of autistic adults live in their own households [14], and many autistic adults with high support needs live in congregate care settings (e.g., long-term care facilities or group homes).…”