Integrons and Insertion Sequences Associated with Beta-Lactamases

Jamali, Sana

doi:10.1007/978-981-16-9097-6_11

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Insertion sequence (IS) are the smallest MGE (< 2.5 kb) to be associated with bla ESBL genes [51]. Together with class 1 integrons, ISEcp1, IS26, IS903 and ISCR1 play a signi cant role in β-lactam resistance [52]. A previous study in Spain documented co-occurrence of intI1 and intI2 (8%) among ESBL-P E. coli isolates with majority having at least three (3) IS elements.…”

Section: Discussionmentioning

confidence: 99%

Extended Spectrum Betalactamase Research mapping; a 32-year Temporal and geographical perspective.

Suleiman

Abdulmalik

Ghazali

2022

Preprint

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Background β-lactam inactivating enzymes like Extended Spectrum β-lactamases (ESBL) have been the focus of the scientific community for decades. The current study assesses the scientific focus on ESBLs based on the temporal succession of ESBL producing pathogens, ESBL types, the blaESBL gene, antibacterial agents, co-existence of resistance determinants, and clonal lineages over a 32-year period. Method Bibliometric indices of publications between 1990 and 2022 were assessed. Network mapping, visualizations and text mining were rendered with Bibliometrix package in R- studio and Visualization of Similarities (VOS) Viewer software. Results A total of 8890 documents were retrieved, with 6246 (70.3 percent) articles in the Medical and Health Sciences category. Despite being the most productive country, with 956 (10.8%) articles published, none of the top 20 institutions were from the United States. Four Spanish and three French institutions made the top ten. Despite the fact that the number and type of antimicrobial agents indicated against ESBL producing organisms changed over time, the preference for Piperacillin/Tazobactam remained consistent for decades. Pseudomonas aeruginosa, Klebsiella pneumonia, and Escherichia coli were the most frequently encountered pathogens of clinical and veterinary importance. E. coli clones (ST(s) 131, 117, 69, 73, 95, 410, 648, 10 and ST38) and K. pneumoniae clones (ST(s) 101, 15, 307, 147, 11, 405, 16 and 23) were the most frequently reported. Previous research also highlighted 'Emerging therapy' based on a 'new ESBL gene' and 'globalization of CTX-M'. Recent top-cited studies focused on 'hypervirulence' and MDR in invasive Klebsiella sp ', 'newer β-lactam/β-lactamase inhibitor (BLBLI) combinations,' and a 'new ultra-broad-spectrum' β-lactamase inhibitor of serine metallo-β-lactamases (QPX7728). Another notable subtheme has been the spread of ESBL and 'Carbapenemase Encoding Genes' in the 'natural aquatic environment'. Conclusion ESBLs are highly researched members of the beta-lactamase family with over 256,980 citations and counting. The scientific community is focused on the mitigation of plasmid mediated spread of ESBLs especially blaCTX−M gene. Reducing mortality by the development of a clinical cure for ESBL infections is a major trend in human and veterinary medicine. Workable multi-country research collaborations are compulsory to consolidate regional guidelines for AMR into a global one.

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Section: Discussionmentioning

confidence: 99%

Extended Spectrum Betalactamase Research mapping; a 32-year Temporal and geographical perspective.

Suleiman

Abdulmalik

Ghazali

2022

Preprint

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Evolution and Emergence of Antibiotic Resistance in Given Ecosystems: Possible Strategies for Addressing the Challenge of Antibiotic Resistance

et al. 2022

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Antibiotics were once considered the magic bullet for all human infections. However, their success was short-lived, and today, microorganisms have become resistant to almost all known antimicrobials. The most recent decade of the 20th and the beginning of the 21st century have witnessed the emergence and spread of antibiotic resistance (ABR) in different pathogenic microorganisms worldwide. Therefore, this narrative review examined the history of antibiotics and the ecological roles of antibiotics, and their resistance. The evolution of bacterial antibiotic resistance in different environments, including aquatic and terrestrial ecosystems, and modern tools used for the identification were addressed. Finally, the review addressed the ecotoxicological impact of antibiotic-resistant bacteria and public health concerns and concluded with possible strategies for addressing the ABR challenge. The information provided in this review will enhance our understanding of ABR and its implications for human, animal, and environmental health. Understanding the environmental dimension will also strengthen the need to prevent pollution as the factors influencing ABR in this setting are more than just antibiotics but involve others like heavy metals and biocides, usually not considered when studying ABR.

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Integrons and Insertion Sequences Associated with Beta-Lactamases

Cited by 2 publications

References 55 publications

Extended Spectrum Betalactamase Research mapping; a 32-year Temporal and geographical perspective.

Extended Spectrum Betalactamase Research mapping; a 32-year Temporal and geographical perspective.

Evolution and Emergence of Antibiotic Resistance in Given Ecosystems: Possible Strategies for Addressing the Challenge of Antibiotic Resistance

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