Integron-associated antimicrobial resistance in isolates of members of Enterobacteriaceae causing community-acquired urinary infections

Dakić, Ivana; Lilakos, Dinos; Švabić-Vlahović, Milena; Christofilopoulou, Sofia; Poggas, Nikos; Charvalos, Ekatherina

doi:10.1080/08910600701442773

Cited by 3 publications

(2 citation statements)

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“…A number of studies have investigated the prevalence of integrons in hospital isolates of Gram -negative bacilli and somewhat conflicting results were obtained [10]. Some studies of selected clinical bacterial populations have shown a high integron prevalence ranging from 28.5 to 89.2% [8,23].…”

Section: Integronsmentioning

confidence: 99%

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Integron-Associated Multidrug Resistance among Gram-Negative Bacteria: A Review

Li¹,

Fc²,

Ia³

et al. 2018

Microbiol Infect Dis

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Multidrug Resistance (MDR) by Gram-negative bacteria is no longer a mystery as studies by researchers has revealed that integrons are amongst the genetic elements responsible for antimicrobial resistance. Integrons are known to consist of Integrase gene, attI site and promoter region. Integrons harbours gene cassettes containing various MDR genes. Polymerase chain reaction and Gel electrophoresis are one of the common ways of detecting integrons in Gram-negative bacteria. As at the time of this review, 4 classes of integrons have been discovered by scientists with only class 1-3 known to be capable of inducing antibiotic resistance in Gram-negative bacteria. However, class 4 integrons found in Vibrio cholerae does not contain gene cassettes probably making it difficult for researchers and scientists to link it to antibiotic resistance. In Nigeria, integrons survey seems to have only been carried out in the south. Thus, it is imperative to conduct studies regarding the presence and distribution of integrons in the North and other areas where the survey has not been carried out in order to create awareness and promote antimicrobial resistance vigilance. The search for novel anti-integron genes compounds should be encouraged in order to tackle the antimicrobial resistance problems in pathogenic Gram-negative bacteria.

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Section: Integronsmentioning

confidence: 99%

“…Integrons are usually, if not completely, associated with Gramnegative bacteria especially members of the enterobacteriaceae. Several studies have been conducted by researchers including the use of molecular detection techniques to reveal the presence of integrons in Enterobacteriaceae [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%