Integrity Testing

Jornitz, Maik W.

doi:10.1007/b104248

Cited by 5 publications

(2 citation statements)

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“…Similar work by Leahy and Sullivan (1978) and Reti et al (1979) confirmed the results established by Johnson and Meltzer (1979). All plots produced a straight line with a slope of two, indicating the strong dependence of a microfilter's microorganism retention capability on its bubble point pressure (Jornitz et al, 1998).…”

Section: Direct Integrity Monitoring Techniquesmentioning

confidence: 99%

Monitoring the Integrity of low‐pressure membranes

Farahbakhsh¹,

Adham²,

Smith³

2003

Journal AWWA

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The main force driving the burgeoning use of low‐pressure membranes in the drinking water industry has been their ability to remove microbial pathogens to meet stringent water quality regulations. However, the microorganism removal efficacy of low‐pressure membranes may be adversely affected by the lack of membrane integrity. Over the past two decades, membrane manufacturers have developed various direct and indirect tests for monitoring the integrity of low‐pressure membranes. Many states currently require such tests to be conducted on a regular basis. The most widely used practice in the membrane water treatment industry is the use of the pressure hold (i.e., pressure decay) test for detecting minor breaches of membrane integrity; particle counting and/or turbidity monitoring are used to meet regulatory requirements and to detect more pronounced breaches in membrane integrity. This article summarizes the current state of knowledge about integrity monitoring methods for membrane filtration systems.

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Section: Direct Integrity Monitoring Techniquesmentioning

confidence: 99%

Monitoring the Integrity of low‐pressure membranes

Farahbakhsh¹,

Adham²,

Smith³

2003

Journal AWWA

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“…A pressurized gas, typically air or nitrogen, on the upstream side of the membrane provides a driving force for diffusion across the wetted membrane. Membrane defects or damage can result in thinning of the liquid layer under pressure and higher diffusive flow (Jornitz, 2006). Very small holes or defects generate full convective flows that are significantly higher than the background diffusive flow.…”

Section: Introductionmentioning

confidence: 98%

Multi‐round virus filter integrity test sensitivity

Dowd

2009

Biotech & Bioengineering

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Virus filtration is becoming increasingly prominent in biopharmaceutical recovery processes as a robust method to remove a broad range of virus types. Increasing batch sizes will require large numbers of individual virus filter elements operating in parallel. Before adopting a more complex strategy for managing the integrity testing of large assemblies of virus filters, it is important to understand the sensitivity of the forward flow diffusion test for a single filter and for multiple filters in a single housing. An approach has been developed to estimate the largest hole that could consistently go undetected in a single filter within a larger assembly of virus filters. The integrity test limited minimum log reduction value (LRV) is determined based on the size of the hole as a function of the number of filters in the housing. This minimum LRV is shown to be largely insensitive to the number of filters within the housing. The likelihood of such damage occurring is expected to be very low. This analysis suggests there is minimal benefit to placing filters in individual housings or to adjusting the test specification to compensate for larger numbers of filters in a given housing.

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Translation of Radiopharmaceuticals from Bench to Bedside: Regulatory and Manufacturing Issues

Knapp

Dash

2016

Radiopharmaceuticals for Therapy

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Integrity Testing

Cited by 5 publications

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Monitoring the Integrity of low‐pressure membranes

Monitoring the Integrity of low‐pressure membranes

Multi‐round virus filter integrity test sensitivity

Translation of Radiopharmaceuticals from Bench to Bedside: Regulatory and Manufacturing Issues

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