Integrity of venoarteriolar reflex determines level of microvascular skin flow enhancement with intermittent pneumatic compression

Abstract

The integrity of the veno-arteriolar response correlates with the level of skin blood flow augmentation generated with intermittent pneumatic compression, indicating that this may be associated with a transient suspension of the autoregulatory vasoconstriction both in healthy controls and in patients with PAD.

Sequential Compression Biomechanical Device Versus Primary Amputation in Patients With Critical Limb Ischemia

“…26 However, our results contradict the finding of Wahlberg et al and Cisek .731 c Abbreviation: pts, patients; SCBD, sequential compression biomechanical device. a There was no significant difference in the diseased vessels apart from a lower incidence of popliteal artery involvement and a higher incidence of tibioperoneal trunk involvement in patients with SCBD.…”

Evaluation of hyperspectral technology for assessing the presence and severity of peripheral artery disease

“…This has been demonstrated by increased skin blood flow in PAD limbs in the dependent position (which was the case in our study) due to decreased precapillary resistance. 17 As the hyperspectral imager gathers data from the subpapillary plexus, it can be thought to examine this increased dependent skin blood flow, which could manifest as unaffected oxyhemoglobin levels with decreased deoxyhemoglobin levels due to less than maximal oxygen extraction in more perfused skin.…”

The effect of aging on the cutaneous microvasculature

“…Optimal healing strategies following surgery and other stressors must therefore use multifactorial approaches to address changes in the microcirculation in the older host (Bentov and Reed, 2014). Potential strategies include maintaining euthermia and euvolemia, better use of existing vessels to optimize vasodilation (e.g., physical activity, pneumatic compression, or pharmacologic mediators) (Husmann et al, 2008; Krcma et al, 2009), optimization of inflammatory and other cellular responses (e.g., stem cells) (Jadlowiec et al, 2012; Roubelakis et al, 2014), and strategies to address deficiencies in growth factors and sex steroids (Jadlowiec et al, 2012; Makrantonaki and Zouboulis, 2009; Scalia, 2013). We will review the anatomical and functional changes in the microcirculation with aging and some of the available strategies to potentially mitigate the effect of these changes on important clinical outcomes.…”