2005
DOI: 10.1073/pnas.0509224102
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Integrity matters: Linking nuclear architecture to lifespan

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Cited by 13 publications
(12 citation statements)
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“…Mutations in the genes encoding lamin A and its binding partners have been associated with a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, limb girdle muscular dystrophy, Dunnigan-type familial partial lipodystrophy and Hutchinson-Gilford progeria syndrome (Bonne et al, 1999;Cao and Hegele, 2000;Eriksson et al, 2003;Fatkin et al, 1999;Muchir et al, 2000). Lamin A/C deficiency and other kinds of mutation may considerably alter the nuclear lamina, jeopardizing the structural integrity of the nucleus (Fidzianska et al, 1998;Hutchison et al, 2001;Lammerding et al, 2004Lammerding et al, , 2005Worman and Courvalin, 2004;Wilson, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Mutations in the genes encoding lamin A and its binding partners have been associated with a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, limb girdle muscular dystrophy, Dunnigan-type familial partial lipodystrophy and Hutchinson-Gilford progeria syndrome (Bonne et al, 1999;Cao and Hegele, 2000;Eriksson et al, 2003;Fatkin et al, 1999;Muchir et al, 2000). Lamin A/C deficiency and other kinds of mutation may considerably alter the nuclear lamina, jeopardizing the structural integrity of the nucleus (Fidzianska et al, 1998;Hutchison et al, 2001;Lammerding et al, 2004Lammerding et al, , 2005Worman and Courvalin, 2004;Wilson, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…It has also been suggested that premature aging processes could be result of alteration in the structural and functional properties of nuclear lamins and their binding proteins. Wilson [2005] reported that vertebrate Lamins and lamin associated proteins are involved in gene regulation, TGF-b signaling, DNA replication, mRNA transcription and also have fundamental roles in chromatin organization, nuclear architecture and nuclear assembly.…”
Section: Discussionmentioning
confidence: 99%
“…Data from studies with [Wilson et al, 2001[Wilson et al, , 2005 C. elegance, fruitful, xenopus eggs, and cultured mammalian cells suggest that gene expression, cell signaling, chromatin organization are directly or indirectly depend on the nuclear lamina organization.…”
Section: Discussionmentioning
confidence: 99%
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“…Initiation and progression of many diseases are associated with alterations in the structure and function of subcellular and subnuclear components which in turn modify the function of the cell [Cornhill and Roach 1974;Sinzinger et al 1980;Athanasiou and Shieh 2002;Trickey et al 2000; [Lammerding et al 2004;Wilson 2005;Mattout et al 2006]. As another example, various cancer cells have altered nuclear structure and irregularity in shapes and spatial organization of subnuclear structures [Zink et al 2004].…”
Section: Implications In Understanding the State Of Human Health And mentioning
confidence: 99%