Integrins and metastasis

Ganguly, Kirat Kumar; Pal, Samares; Moulik, Shuvojit; Chatterjee, Amitava

doi:10.4161/cam.23840

Cited by 163 publications

(151 citation statements)

References 107 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…Cell invasiveness is known to be promoted by higher levels of integrin β1 receptors (Ganguly et al 2013;Berry et al 2003). Increased α6β4 expression found in certain carcinomas also correlates with invasive properties (Gordon et al 2003).…”

Section: Integrin Expression and Cell Adhesionmentioning

confidence: 99%

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

et al. 2017

View full text Add to dashboard Cite

2018Avhandling for graden philosophiae doctor (ph.d.)Dato for disputas: 06.04.18Trykk:Skipnes Kommunikasjon / Universitetet i Bergen Materialet i denne publikasjonen er omfattet av åndsverkslovens bestemmelser. Tittel:The effects of ageing on microenvironment-contextual epithelial cell signalling Rein Aasland, for valuable insight on academic writing, and for pointing out, as did James, when my words became self-indulgent fun and flowers. Mark LaBarge, for taking me into his lab, and letting me partake in that which concerns absolutely everyone: ageing. To Martha Stampfer for allowing me to poke around in her human cell resources biobank. To James Garbe for being an incredibly sympathetic guy with the most convenient knowledge up his sleeve.I would like to thank my mother Nina-Mamma for never curbing her enthusiasm for tiny biology when I brought home science homework, and my father Ulf for being genuinely impressed with pretty much everything I didincluding when I did it badly. I need to thank my boyfriend, Lars, for meticulous proofreading of the manuscript, and for continuously encouraging me to put my academic whims into writing. I want to point out that Iren Abrahamsen did substantial preliminary work for the microsphere cytometry method. I need to to thank my medical doctor office mates, Gry and Kjersti for valuable insights from the clinical realm where lab rats never go, to remind me who we're doing this for in the first place. Thanks to Sissel for being that steady rock in the corner stall of the lab where PhDs and postdocs fly by. I would like to thank the girls in the lab for taking up the fight against cancer cell Fråtse-Frida, and winning it. Finally, I would like to thank the Cancer Society, VilVite, CCBIO and Forskningsdagene for giving me trust, whether it was to develop flow cytometry protocols or popular science shows, or to interrogate the microenvironment I would like thank just anyone else in the lab and the general world who is interested and willing to contemplate big ideas such as the purpose of being. And at last, every single nerd: nerdy boys and nerdy girls. pathway activation levels in HMEC are attenuated with age, and that the diminished signaling magnitude in HMEC from ageing women correlated with reduced probability of activating oncogene-induced senescence.Our results suggest that attenuated cell signaling response may reduce the likelihood of activating oncogene induced senescence, for cells in ageing women. We hypothesize this is the result of age-related changes to the microenvironment that support age-emergent cellular phenotypes with increased cancer susceptibility.

show abstract

Section: Integrin Expression and Cell Adhesionmentioning

confidence: 99%

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

et al. 2017

View full text Add to dashboard Cite

show abstract

“…b Generic structure of the bound and unbound conformations of the αxβ2 integrin heterodimer [5] Willebrand factor, to name a few [6]. Ligand affinity and the specificity of each individual heterodimer combination are primarily influenced by the presence of additional specific residues/sequences outside of that RGD-binding motif [6]. Ganguly et al have presented evidence that these neighbouring residues may synergistically promote and influence the adhesion of the integrin RGD-binding domain to specific ligands [6].…”

Section: Introductionmentioning

confidence: 97%

“…Predominantly thought to be cell surface ECM receptors, integrins bind to proteins such as collagen IV, laminin, vitronectin, fibronectin and leukocyte-specific ligands in order to mediate cellular adhesion through cell•ECM and also cell•cell interactions [6]. Each α/β combination confers a particular binding specificity and consequential downstream signalling capabilities which underpin the structural and functional diversity of the integrin family (Fig.…”

Section: Introductionmentioning

confidence: 98%

“…1 a Schema of the various α and β subunit integrin heterodimer combinations. b Generic structure of the bound and unbound conformations of the αxβ2 integrin heterodimer [5] Willebrand factor, to name a few [6]. Ligand affinity and the specificity of each individual heterodimer combination are primarily influenced by the presence of additional specific residues/sequences outside of that RGD-binding motif [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Integrin αvβ6 sets the stage for colorectal cancer metastasis

Cantor

Cheruku

Nice

et al. 2015

Cancer Metastasis Rev

View full text Add to dashboard Cite

The β6 subunit of the αvβ6 integrin heterodimer has long been an enigma in cancer biology though recent research has provided many new insights into its biology. Collectively, these findings include discovery of the transcriptional, translational and cell biological mechanisms by which β6 acts, the identification of the cellular influences β6 exerts upon the cell proteome, the characterisation of multiple β6-centric pro-metastatic signalling systems and the search for pharmacological therapies (industry and academia) targeted against β6. Once expressional restriction is overcome in early colorectal cancer (CRC), epithelial cell surface restricted αvβ6 can physically interact with, and activate, known oncoproteins, and has the potential to enable the cross-talk through non-canonical signal transduction pathways, resulting in the adoption of an invasive/metastatic phenotype. This recent research has identified numerous interconnections and potential feedback loops, highlighting the fact that the expression of the β6 subunit may initiate a cascade of downstream effects on the CRC cell rather than acting through a single mechanism. We here review these recent studies and postulate that the existence of a cell surface uPAR/αvβ6/TGFβ "metastasome" interactome in/on a proportion of colorectal cancer cells, where β6 expression sequesters and activates multiple systems at the invasive front of tumour lesions, promoting cancer metastasis and hence explaining why β6 has been correlated with reduced patient survival in CRC.

show abstract

“…Metastasis includes several biochemical events in which biology and mechanisms are complex. Metastasis consists of steps like angiogenesis, invasion stages consisting four different phases (detachment, attachment, proteolysis, and cell migration), intra vascular phase, and extravasation [9]. In addition, metastatic pathways are classified as lymphatic metastasis, hematologic metastasis, and dropped metastasis [8].…”

Section: Introductionmentioning

confidence: 99%

Current surgical management of extrapulmonary oligometastatic non-small cell lung carcinoma

Yazicioğlu¹

2018

Curr Thorac Surg

View full text Add to dashboard Cite

To cite this article: Yazicioglu A. Current surgical management of extrapulmonary oligometastatic non-small cell lung carcinoma. Curr Thorac Surg 2018;3(1):25-37 ABSTRACTLung cancer is one of the leading cause of mortality around the world, and it is widely known that survival is limited in metastatic lung carcinoma cases. However, in oligometastatic, non-small cell lung carcinoma cases, surgical excision of both the primary tumor and the metastatic site may yield a survival advantage in selected cases. In non-small cell lung carcinoma cases, especially after metastasectomy of brain and adrenal gland metastasis, studies in which survival advantage is reported are common in the literature, and metastasectomy is the treatment method applied to selected patient groups in brain and adrenal gland metastases. In surgical treatment of extra-cranial and extra-adrenal oligometastasis, on the other hand, there are several cases in which morbidity-free survival rates were reported after successful management. In this report, the surgical treatment results were evaluated, and the contribution of treatment methods to survival rates were investigated in extrapulmonary oligometastatic non-small cell lung carcinoma cases receiving surgical excision.

show abstract

Integrins and metastasis

Cited by 163 publications

References 107 publications

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

Microsphere cytometry to interrogate microenvironment-dependent cell signaling

Integrin αvβ6 sets the stage for colorectal cancer metastasis

Current surgical management of extrapulmonary oligometastatic non-small cell lung carcinoma

Contact Info

Product

Resources

About