Integrins

Integrins as therapeutic targets: lessons and opportunities

“…Thus, embryonic development 16 and angiogenesis 17 are critically dependent on integrins, as is the immune system 18 in which immune cell attachment is necessary for normal function (see below).…”

Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling

“…Cell spreading and focal adhesion (FA) formation are both important for cell migration 33,34 . HGF-induced cell spreading and FA formation were almost completely inhibited when Arf6 À / À iECs were cultured on the b1 integrin ligands collagen type I, collagen type IV and fibronectin, but not for the b3 integrin ligand vitronectin (Fig.…”

“…Among these, a1b1, a2b1 and a5b1 play roles in tumour angiogenesis 34 . Thus, it is reasonable to conclude that the inhibition of HGF-induced b1 recycling by Arf6 deletion suffices to explain our observed suppression of tumour angiogenesis.…”

Chronic Cerebral Hypoxia Promotes Arteriogenic Remodeling Events that can be Identified by Reduced Endoglin (CD105) Expression and a Switch inβ1 Integrins

“…Integrins have critical roles in regulating vascular remodeling both during development and in the adult (Silva et al, 2008). The a5b1 integrin is expressed at high levels by angiogenic blood vessels in development, downregulated during vessel maturation (Milner and Campbell, 2002) and then reinduced by angiogenic vessels in the adult CNS (Milner et al, 2008a).…”