Integrin α7 is overexpressed and correlates with higher pathological grade, increased T stage, advanced TNM stage as well as worse survival in clear cell renal cell carcinoma patients: A retrospective study

Abstract

Objective This study aimed to explore the association of integrin α7 with clinicopathological characteristics and overall survival (OS) in clear cell renal cell carcinoma (ccRCC) patients. Methods 179 ccRCC patients who underwent nephrectomy were included in this retrospective study. Tumor tissue and paired adjacent tissue specimens of patients were obtained. Immunohistochemistry assay was performed to detect integrin α7 expression. OS was calculated with the median follow‐up duration of 91.0 months (range: 3.0‐116.0 months). Results Integrin α7 was highly expressed in tumor tissue compared to paired adjacent tissue (P < .001), and tumor integrin α7 high expression was correlated with higher pathological grade (P = .004), increased T stage (P = .017), and advanced TNM stage (P = .033). Kaplan–Meier curve showed that patients with integrin α7 high expression (mean OS = 69.8, 95%CI: 60.5‐79.1 months) presented with worse OS compared to patients with integrin α7 low expression (mean OS = 101.8, 95%CI: 96.0‐107.7 months; P < .001). Multivariate Cox's regression analysis further disclosed that tumor integrin α7 high expression independently predicted poor OS (P < .001). Conclusion Integrin α7 is upregulated and correlates with higher pathological grade, increased T stage, and advanced TNM stage, meanwhile it also acts as a valuable prognostic factor for worse survival in ccRCC patients.

ITGA7, CD133, ALDH1 are inter‐correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer

“…7 ITGA7, CD133, and ALDH1 mediate the CSC properties in multiple carcinomas. 9,[11][12][13][14]22,24,29,30 Therefore, overexpression of ITGA7, CD133, and ALDH1 might be correlated with poor differentiation in cervical cancer pathology. So far, former studies have revealed the correlation of ITGA7 expression with prognosis for various neoplasms.…”

“…ITGA7 is reported to be positively linked with the activation of CSCs in multiple carcinomas including tongue SCC, esophageal SCC, renal cell carcinoma as well as non‐small‐cell lung cancer 9,11–13 . Whereas, the role of ITGA7 in regulating the stemness of cervical cancer cells thus further acting as a potential biomarker for the prognosis in cervical cancer patients remains elusive.…”

“…7,8 Integrin alpha 7 (ITGA7) is localized on chromosome 12p13 and consists of at least 27 exons spanning a region of about 22.5 kb, which acts as an oncogene and plays a critical role in facilitating the stemness in multiple carcinomas. [9][10][11][12][13] For instance, prior studies disclose that ITGA7 facilitates the proliferation or metastasis of tumor cells and promotes the activity of CSC in renal cell carcinoma, non-small-cell lung cancer and tongue squamous cell carcinoma (SCC). [11][12][13] In a more in-depth research, ITGA7 upregulates CSC properties through the activation of the focal adhesion kinase (FAK)-mediated signaling pathways in esophageal SCC.…”

To handle the inflation of odds ratios in a retrospective study with a profile penalized log‐likelihood approach

“…The data used to support the findings of this study are included within the article. I-Shiang Tzeng 1,2…”

“…To handle the inflation of odds ratios in a retrospective study with a profile penalized log-likelihood approach Dear Editor, We read with great interest the paper authored by Chen et al 1 entitled "Integrin α7 is overexpressed and correlates with higher pathological grade increased T stage advanced TNM stage as well as worse survival in clear cell renal cell carcinoma patients: A retrospective study," published in January 2020 in the Journal of Clinical Laboratory Analysis. The authors aimed to explore the association of integrin α7 with clinicopathological characteristics and overall survival (OS) in patients with clear cell renal cell carcinoma (ccRCC) based on a retrospective study.…”