Integrin Mechanosensing relies on Pivot-clip Mechanism to Reinforce Cell Adhesion
Andre R. Montes,
Anahi Barroso,
Wei Wang
et al.
Abstract:Cells intricately sense mechanical forces from their surroundings, driving biophysical and biochemical activities. This mechanosensing phenomenon occurs at the cell-matrix interface, where mechanical forces resulting from cellular motion, such as migration or matrix stretching, are exchanged through surface receptors, primarily integrins, and their corresponding matrix ligands. A pivotal player in this interaction is the α5β1 integrin and fibronectin (FN) bond, known for its instrumental role in establishing n… Show more
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