“…Considering the pro-survival effects of LN-5 discussed above, it is possible that adhesion to newly deposited LN-5 also contributes to keratinocyte survival during migration into the provisional wound ECM. LN-5, α3β1 and α6β4 are also expressed at high levels in many invasive carcinomas, suggesting possible roles for these adhesion proteins in promoting tumor cell invasion and survival, as well (Dajee et al, 2003;Felding-Habermann, 2003;Bartolazzi et al, 1994;Natali et al, 1993;Patriarca et al, 1998;Lohi et al, 2000;Pyke et al, 1995). Indeed, previous studies have suggested that α6β4 promotes survival of normal or transformed epithelial cells (Dowling et al, 1996;Weaver et al, 2002;Bachelder et al, 1999), possibly through activation of PI3K (Shaw et al, 1997).…”