“…Moreover, this microglia‐driven oxidative stress will lead to oxidation of a‐syn in nearby cells which will further feed the neuro‐toxic process (Shavali, Combs, & Ebadi, ). The a‐syn‐induced oxidative stress has been related to CD11b and resultant PHOX NADPH oxidase activation (Hou et al., ; Jin et al., ; Zhang et al., , ). Multiple labs have shown now that a‐syn can initiate a pro‐inflammatory response in microglia inducing production of IL‐6, IL‐1β, and TNF (Couch, Alvarez‐Erviti, Sibson, Wood, & Anthony, ; Klegeris et al., ; Lee et al., , ; Roodveldt et al., ; Su et al., ).…”