Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis

Nikolopoulos, Georgios K.; Tsantes, Argirios Ε.; Bagos, Pantelis G.; Travlou, Αnthi; Vaiopoulos, G

doi:10.1016/j.thromres.2006.04.002

Cited by 39 publications

(35 citation statements)

References 35 publications

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“…Subgroup analyses stratified according to HWE, sample size, and ethnicity also showed significant associations with ischemic stroke susceptibility. This result differed from that of the meta-analysis carried out by Nikolopoulos et al (2007), where only 7 independent studies were included. Here we present updated results on the crucial role of C807T(C/T) polymorphism in ischemic stroke.…”

Section: Discussioncontrasting

confidence: 74%

Association between C807T(C/T) polymorphism of platelet glycoprotein gene and sensitivity to ischemic stroke: a meta-analysis

et al. 2017

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ABSTRACT. Ischemic stroke can lead to loss of neurologic functions. It occurs due to obstruction in blood supply to the brain. It has been proposed that C807T(C/T) polymorphism within the platelet glycoprotein gene may be associated with density and function of glycoprotein Ia/IIa receptors and contributes to the pathogenesis of thrombotic disease. We assessed the association between C807T(C/T) and risk of ischemic stroke. Databases such as PubMed, Medline, Springer, Elsevier Science Direct, Cochrane Library, Google scholar, Wanfang Data (Chinese), and Chinese National Knowledge Infrastructure (CNKI, Chinese) were used to search for relevant studies. We found 16 eligible studies, which totaled to 4897 (case group 2340; control group 2557) participants. Overall, our results showed significant associations between C807T(C/T) polymorphism and risk of ischemic stroke based on T-allele comparisons (T vs C, pooled OR = 0.78, 95%CI = 0.68-0.90, P < 0.01), TT vs CC comparisons (pooled OR = 0.58, 95%CI = 0.42-0.81, P < 0.01), recessive models (TT vs TC + CC, pooled OR = 0.72, 95%CI = 0.59-0.87, P < 0.01) and dominant models (TT + TC vs CC, pooled OR = 0.70, 95%CI = 0.54-0.92, P < 0.05). There was no association in TC vs CC comparisons (pooled OR = 0.81, 95%CI = 0.63-1.04, P > 0.05). Subgroup analyses stratified according to Hardy-Weinberg equilibrium, sample size, and ethnicity also demonstrated significant associations between the two variables. Therefore, C807T(C/T) polymorphism in the platelet glycoprotein gene may be associated with susceptibility to ischemic stroke, and the T allele at this locus may decrease risk to ischemic stroke.

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Section: Discussioncontrasting

confidence: 74%

Association between C807T(C/T) polymorphism of platelet glycoprotein gene and sensitivity to ischemic stroke: a meta-analysis

et al. 2017

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“…[21,22]. studies that investigated possible association of these polymorphisms with myocardial infarction and stroke [11][12][13] . Carlsson et al [12] and Nikolopoulos et al [13] observed association of stroke in younger individuals with 807T allele.…”

Section: Methodsmentioning

confidence: 99%

“…Patients with quantitative abnormalities of platelet α2 present with prolonged bleeding times, chronic mucocuatneous bleeding, defective in vitro platelet adhesion to collagen and absent in vitro collagen induced aggregation [3,4]. The gene encoding α2 integrin has at least 8 polymorphisms, including two silent polymorphisms located within the I domain [5], Phe (TTT/TTC) due to a T/ Moreover, some recent studies had shown relationship between this polymorphism and the prevalence of myocardial infarction [11], stroke [12,13], as well as diabetic retinopathy [14]. There are also studies that have shown influence of this polymorphism on aspirin and clopidogrel efficacy [15].…”

Section: Introductionmentioning

confidence: 99%

<i>Bgl II</i> Polymorhism of the α2β1 Integrin Gene in Macedonian Population

Pavkovic¹,

Petlichkovski²,

Stojanović³

et al. 2010

Macedonian Journal of Medical Sciences

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Background. Glycoprotein (GP) Ia/IIa or α2β1 integrin is a platelet receptor for collagen and it mediates platelet adhesion to vascular subendothelium and is involved in thromb formation. Genetic polymorphism of α2β1 known as Bgl II affects the density of platelet GP Ia/IIa receptor on the platelet surface. Recent studies had shown relationship between this polymorphism and the risk of myocardial infarction, stroke, as well as diabetic retinopathy.

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“…74 Conversely, 2 meta-analyses published in 2007 and including 9 and 7 studies, respectively, showed that the GPIa C807T polymorphism is not a significant risk factor for CAD 75 and ischemic stroke. 76 A recent meta-analysis including 15 studies with a total number of 2242 cases and 2408 controls reported an association between the GPIa C807T polymorphism and risk of ischemic stroke in the overall population, in Asians and in the subgroup of hospitalized patients, but not in Caucasians and nonhospitalized individuals. 77 Croft et al 78 investigated 525 patients with acute MI and 474 controls and showed that the GPVI 13254CC genotype increased the risk of MI, particularly in patients aged 60 years and older (OR, 6.48; 95% CI, 1.47-28.45; P = 0.009).…”

Section: 54mentioning

confidence: 99%