This work presents a detailed review and comparative analysis of the process design and economics of n-butanol production using corn grain and corn stover. This includes reviewing the most recent n-butanol technologies; demonstrating the impact of key parameters (e.g. plant capacity, raw material pricing, yield) on the overall n-butanol process economics; and comparing how cellulosic biomass conversion technologies and challenges differ from traditional sugar-based n-butanol conversion technology. A major challenge of n-butanol production is the low n-butanol yield (compared to ethanol), resulting in higher production costs. However, recent research efforts have achieved signifi cant yield improvements using a combination of genetic engineering, fermentation techniques, and integrated process development using continuous fermentation with online stripping to remove n-butanol during fermentation. This study presents the advances in n-butanol research for both sugar-based (corn) and cellulosic (corn stover) feedstocks, and also provides a comparison of overall process technologies and process economics. In addition, the results of a sensitivity analysis comparing various technologies, sugar yields, and coproduct distributions are discussed in order to provide research guidance.