Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

Qiu, Xinzhu; He, Hongbo; Zeng, Hao; Tong, Xiaopeng; Zhang, Can; Liu, Yupeng; Liao, Zhongxing; Liu, Qing

doi:10.1016/j.gendis.2023.04.035

Cited by 2 publications

(2 citation statements)

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“…Elevated expression of MYBL2 in various tumors is often associated with poor prognosis ( 45 , 46 ), rendering it a potential therapeutic target in cancer treatment. As a prognostic indicator of unfavorable outcomes in osteosarcoma and a universal marker for immune infiltration across various cancers, MYBL2 exerts regulatory control over proliferation, tumor advancement, and immune cell infiltration within osteosarcoma and broader cancer contexts ( 47 ). In clear cell renal carcinoma, MYBL2 promotes malignant characteristics and impedes apoptosis through activation of the hedgehog signaling pathway ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Integrated machine learning identifies a cellular senescence-related prognostic model to improve outcomes in uterine corpus endometrial carcinoma

Wei,

Lin,

Huang

et al. 2024

Front. Immunol.

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BackgroundUterine Corpus Endometrial Carcinoma (UCEC) stands as one of the prevalent malignancies impacting women globally. Given its heterogeneous nature, personalized therapeutic approaches are increasingly significant for optimizing patient outcomes. This study investigated the prognostic potential of cellular senescence genes(CSGs) in UCEC, utilizing machine learning techniques integrated with large-scale genomic data.MethodsA comprehensive analysis was conducted using transcriptomic and clinical data from 579 endometrial cancer patients sourced from the Cancer Genome Atlas (TCGA). A subset of 503 CSGs was assessed through weighted gene co-expression network analysis (WGCNA) alongside machine learning algorithms, including Gaussian Mixture Model (GMM), support vector machine - recursive feature elimination (SVM-RFE), Random Forest, and eXtreme Gradient Boosting (XGBoost), to identify key differentially expressed cellular senescence genes. These genes underwent further analysis to construct a prognostic model.ResultsOur analysis revealed two distinct molecular clusters of UCEC with significant differences in tumor microenvironment and survival outcomes. Utilizing cellular senescence genes, a prognostic model effectively stratified patients into high-risk and low-risk categories. Patients in the high-risk group exhibited compromised overall survival and presented distinct molecular and immune profiles indicative of tumor progression. Crucially, the prognostic model demonstrated robust predictive performance and underwent validation in an independent patient cohort.ConclusionThe study emphasized the significance of cellular senescence genes in UCEC progression and underscored the efficacy of machine learning in developing reliable prognostic models. Our findings suggested that targeting cellular senescence holds promise as a strategy in personalized UCEC treatment, thus warranting further clinical investigation.

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Section: Discussionmentioning

confidence: 99%

Integrated machine learning identifies a cellular senescence-related prognostic model to improve outcomes in uterine corpus endometrial carcinoma

Wei,

Lin,

Huang

et al. 2024

Front. Immunol.

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show abstract

“…Elevated expression of MYBL2 in various tumors is often associated with poor prognosis (45,46), rendering it a potential therapeutic target in cancer treatment. As a prognostic indicator of unfavorable outcomes in osteosarcoma and a universal marker for immune infiltration across various cancers, MYBL2 exerts regulatory control over proliferation, tumor advancement, and immune cell infiltration within osteosarcoma and broader cancer contexts (47). In clear cell renal carcinoma, MYBL2 promotes malignant characteristics and impedes apoptosis through activation of the hedgehog signaling pathway (48).…”

Section: Discussionmentioning

confidence: 99%

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Integrative transcriptome analysis identifies MYBL2 as a poor prognosis marker for osteosarcoma and a pan-cancer marker of immune infiltration

Cited by 2 publications

References 45 publications

Integrated machine learning identifies a cellular senescence-related prognostic model to improve outcomes in uterine corpus endometrial carcinoma

Integrated machine learning identifies a cellular senescence-related prognostic model to improve outcomes in uterine corpus endometrial carcinoma

DataSheet_2.csv

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