Integrative TCM Conservative Therapy for Low Back Pain due to Lumbar Disc Herniation: A Randomized Controlled Clinical Trial

Wang, Yuan; Huang, Shi Rong; Guo, Kai; Sun, Wu; Xi, Xiao Bing; Zhang, Ming Cai; Kong, Lingjun; Lu, Hai-Ying; Zhan, Hongsheng; Cheng, Ying Wu

doi:10.1155/2013/309831

Cited by 12 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another trial conducted in China demonstrated [26] that the decrease in the mean value of the leg pain intensity NRS score in the EA group was 4.65 ± 6.37 at week 4, which was higher than the value of 2.30 (1.86–2.75) obtained in our trial at the same time point. In a pilot trial comparing EA with physical therapy for symptomatic lumbar spinal stenosis (LSS) [27], pain in the back and leg showed small improvements at 3 months.…”

Section: Discussioncontrasting

confidence: 91%

A Randomized Clinical Trial Comparing the Effectiveness of Electroacupuncture versus Medium‐Frequency Electrotherapy for Discogenic Sciatica

Zhang

Wang

Wenyuan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. To investigate the short- and long-term effects of electroacupuncture (EA) compared with medium-frequency electrotherapy (MFE) on chronic discogenic sciatica. Methods. One hundred participants were randomized into two groups to receive EA (n = 50) or MFE (n = 50) for 4 weeks. A 28-week follow-up of the two groups was performed. The primary outcome measure was the average leg pain intensity. The secondary outcome measures were the low back pain intensity, Oswestry Disability Index (ODI), patient global impression (PGI), drug use frequency, and EA acceptance. Results. The mean changes in the average leg pain numerical rating scale (NRS) scores were 2.30 (1.86–2.57) and 1.06 (0.62–1.51) in the EA and MFE groups at week 4, respectively. The difference was significant (P < 0.001). The long-term follow-up resulted in significant differences. The average leg pain NRS scores decreased by 2.12 (1.70–2.53) and 0.36 (−0.05–0.78) from baseline in the EA and MFE groups, respectively, at week 28. However, low back pain intensity and PGI did not differ significantly at week 4. No serious adverse events occurred. Conclusions. EA showed greater short-term and long-term benefits for chronic discogenic sciatica than MFE, and the effect of EA was superior to that of MFE. The study findings warrant verification. This trial was registered under identifier ChiCTR-IPR-15006370.

show abstract

Section: Discussioncontrasting

confidence: 91%

A Randomized Clinical Trial Comparing the Effectiveness of Electroacupuncture versus Medium‐Frequency Electrotherapy for Discogenic Sciatica

Zhang

Wang

Wenyuan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Some studies have reported the effectiveness of herbal medicine, which is the most popular form of complementary and alternative medical therapy for the treatment of LDH, either used alone or concomitantly with usual care. [ 9 , 15 , 16 ] The limited quality and small sample sizes of the few trials that have been conducted to date have made it difficult to reach firm conclusions about TCM treatments. Well-designed randomized controlled trials are needed to examine the efficacy of TCM treatments for LDH.…”

Section: Discussionmentioning

confidence: 99%

“…In this trial, we refer to the literature [ 9 , 15 – 17 ] and set the inclusion criteria as follows: (1) age 20 to 60 years;…”

Section: Methodsmentioning

confidence: 99%

“…Some studies have confirmed that some TCM therapies has a certain therapeutic effect on lumbar back pain caused by lumbar disc herniation and stimulates the resorption of herniated disc. [ 9 , 15 – 17 ] However, the limited quality and small number of subjects of the few trials that have been conducted have made it difficult to reach firm conclusions about these treatments. High quality research evidence is needed to support the effectiveness of TCM regimens.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical research for whether the Traditional Chinese medicine could promote the resorption of lumbar disc herniation: a randomized controlled trial

et al. 2020

View full text Add to dashboard Cite

Lumbar disc herniation (LDH) is a common, disabling musculoskeletal disorder. Magnetic resonance imaging has clarified the natural history of lumbar disc lesions and has documented that disc lesions can become smaller and can even be completely resorbed. Previous studies have confirmed that some traditional Chinese medicine (TCM) therapies can promote resorption of the protrusion. However, high-quality research evidence is needed to support the effectiveness of the protocol. Objective: This clinical trial aims to establish whether TCM can promote the resorption of LDH and to assess the efficacy of such therapy for LDH, thereby evaluating its clinical effect. Methods: The present study design is for a single-center, 2-arm, open-label randomized controlled trial. A total of 150 eligible LDH patients will be randomly assigned to either a TCM treatment group or a control group in a 1:1 ratio. Patients in the TCM group will be administered a TCM decoction for 4 weeks. Patients in the conventional drug control group will be instructed to take a specific daily dose of celecoxib. The primary outcome measure is the change from baseline in the volume of the protrusion, as assessed using MR images. Secondary outcome measures include visual analog scale pain scores and Japanese Orthopaedic Association scores assessed at 3 and 6 months. Discussion: The design and methodological rigor of this trial will allow evaluation of the basic clinical efficacy and safety data for TCM in the treatment of patients with LDH. The trial will also assess whether TCM can promote the resorption of LDH. This research will therefore help provide a solid foundation for the clinical treatment of LDH and for future research in TCM therapy. Trial registration: ChiCTR1900022377.

show abstract

“…[17,18,19,20,21] As a treasure of China, TCM has unique advantages in the treatment of some chronic complex diseases. [22,23,24] Shujinjianyao pill (SJJYP) is a kind of Chinese patent medicine containing many kinds of traditional Chinese herbs, which is mainly used to treat low back pain, sciatica, and other diseases in clinic. [25,26,27] However, there is no study that has been conducted on its safety.…”

Section: Introductionmentioning

confidence: 99%

Safety of Shujinjianyao pill in clinical real world

Cui

Liang²,

Wang

et al. 2019

Medicine

View full text Add to dashboard Cite

Background:Low back pain is a common health problem worldwide, which also is a leading cause of long-term disability and has an important effect on the global economy and society. Usually, conservative therapies are used to treat low back pain. As a kind of Chinese patent medicine, Shujinjianyao pill (SJJYP) has a great curative effect on low back pain. However, its safety has not been studied yet. Therefore, we carried out this clinical trial to observe the safety of SJJYP in the real world.Methods:First, participants need to meet the medication standards according to inclusion and exclusion criteria. Then, participants are conducted safety examination before taking SJJYP. After qualified screening, participants can be enrolled into the group. Second, all enrolled participants will receive SJJJYP for a period of 4 weeks. During the observation period, participants need to return to the hospital for a subsequent visit after 2 weeks of medication, and come to the hospital for safety check after 4 weeks of medication. Third, telephone follow-up is used to investigate any participants’ physical discomfort after 6 to 8 weeks (2–4 weeks after medication withdrawal). After all these steps are completed, clinical observation is finished. If any adverse events occur during this process, we will record them in time. When serious adverse events occur, we will use nested case–control study to explore the causes and mechanisms.Discussion:This study will obtain the safety results of SJJYP in clinical real world, which will offer a scientific basis for clinicians in the treatment of low back pain, and also provide a methodological basis for the safety study of other medicines.Trial registration:ClinicalTrial.gov registration number is NCT03598153. This study was approved by the ethics committee of Wangjing hospital, China Academy of Chinese Medical Sciences (WJEC-KT-2018-012-P002).

show abstract

Integrative TCM Conservative Therapy for Low Back Pain due to Lumbar Disc Herniation: A Randomized Controlled Clinical Trial

Cited by 12 publications

References 11 publications

A Randomized Clinical Trial Comparing the Effectiveness of Electroacupuncture versus Medium‐Frequency Electrotherapy for Discogenic Sciatica

A Randomized Clinical Trial Comparing the Effectiveness of Electroacupuncture versus Medium‐Frequency Electrotherapy for Discogenic Sciatica

Clinical research for whether the Traditional Chinese medicine could promote the resorption of lumbar disc herniation: a randomized controlled trial

Safety of Shujinjianyao pill in clinical real world

Contact Info

Product

Resources

About