“…Here, we introduce features of MMMx for improved design of experiments. An important issue in such experimental studies is the comparison of ensembles obtained with different restraint sets or with different modeling approaches (Aina et al, 2023; Brüschweiler, 2003; Dorn et al, 2023; González‐Delgado et al, 2023; Huihui & Ghosh, 2020, 2021; Lazar et al, 2020; Lindorff‐Larsen & Ferkinghoff‐Borg, 2009; Tiberti et al, 2015). Here, we introduce a single‐valued similarity measure that abstracts from the ensemble width.…”