Integrative single-nucleus multi-omics analysis prioritizes candidatecisandtransregulatory networks and their target genes in Alzheimer’s disease brains
Abstract:BackgroundThe genetic underpinnings of late-onset Alzheimer’s disease (LOAD) are yet to be fully elucidated. Although numerous LOAD-associated loci have been discovered, the causal variants and their target genes remain largely unknown. Since the brain is composed of heterogenous cell subtypes, it is imperative to study the brain on a cell subtype specific level to explore the biological processes underlying LOAD.MethodsHere, we present the largestparallelsingle-nucleus (sn) multi-omics study to simultaneously… Show more
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