Integrative single‐cell transcriptome analysis provides new insights into post‐COVID‐19 pulmonary fibrosis and potential therapeutic targets
Yumin Kim,
Yeongmin Kim,
Hyobin Julianne Lim
et al.
Abstract:The global COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 virus has resulted in a significant number of patients experiencing persistent symptoms, including post‐COVID pulmonary fibrosis (PCPF). This study aimed to identify novel therapeutic targets for PCPF using single‐cell RNA‐sequencing data from lung tissues of COVID‐19 patients, idiopathic pulmonary fibrosis (IPF) patients, and a rat transforming growth factor beta‐1‐induced fibrosis model treated with antifibrotic drugs.… Show more
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