Integrative role of small non-coding RNAs in viral immune response: a systematic review

Suleiman, Ahmed AbdulJabbar; Al-Chalabi, Rawaa; Shaban, Semaa A.

doi:10.1007/s11033-023-09141-6

Cited by 2 publications

(4 citation statements)

References 83 publications

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“…Finally, the association of h-tRNAs with viral infections is undoubtedly one of the most surprising examples. tRNAs can be processed into small fragments known as tRFs, currently also known as tiRNAs [3], in addition to their conspicuous organization in eukaryotes [104,105]. tiRNAs can directly or indirectly influence RSV replication [106], viral gene expression during HCV infection [107], and antiviral immunity.…”

Section: Category: Shape Of the Rna Genome And The Processing Of Vira...mentioning

confidence: 99%

“…A fraction of the pervasive transcription of the human genome includes noncoding RNAs, such as microRNA (miRNA), piwi-interacting RNA (piRNA), long noncoding RNA (lncRNA), circular RNA (circRNA), transfer RNA-derived stress-induced RNA (tiRNA), small nucleolar RNAs (snoRNA), and small nuclear RNAs (snRNAs) [1][2][3]. However, uncovering their role in viral infections is challenging, and only for miRNAs and lncR-NAs has it been better understood.…”

Section: Introductionmentioning

confidence: 99%

“…However, uncovering their role in viral infections is challenging, and only for miRNAs and lncR-NAs has it been better understood. miRNAs bind mainly to the 3 ′ untranslated region (3 ′ UTR) of a target messenger RNA (mRNA) to regulate gene expression [3,4] through miRNA-mRNA (RNA-RNA) interactions, which end in mRNA degradation or translation regulation. LncRNAs are emerging regulators of multiple biological processes.…”

Section: Introductionmentioning

confidence: 99%

“…We do not attempt to provide a comprehensive survey of all the viral-derived RNAs. Our recommendation for miRNAs is the following reviews: [2,3,[16][17][18][19][20][21][22], and for lncRNAs, these publications [7,23,24].…”

Section: Introductionmentioning

confidence: 99%

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Toward a Categorization of Virus-ncRNA Interactions in the World of RNA to Disentangle the Tiny Secrets of Dengue Virus

Bermudez-Santana,

Gallego-Gómez

2024

Viruses

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In recent years, the function of noncoding RNAs (ncRNAs) as regulatory molecules of cell physiology has begun to be better understood. Advances in viral molecular biology have shown that host ncRNAs, cellular factors, and virus-derived ncRNAs and their interplay are strongly disturbed during viral infections. Nevertheless, the folding of RNA virus genomes has also been identified as a critical factor in regulating canonical and non-canonical functions. Due to the influence of host ncRNAs and the structure of RNA viral genomes, complex molecular and cellular processes in infections are modulated. We propose three main categories to organize the current information about RNA–RNA interactions in some well-known human viruses. The first category shows examples of host ncRNAs associated with the immune response triggered in viral infections. Even though miRNAs introduce a standpoint, they are briefly presented to keep researchers moving forward in uncovering other RNAs. The second category outlines interactions between virus-host ncRNAs, while the third describes how the structure of the RNA viral genome serves as a scaffold for processing virus-derived RNAs. Our grouping may provide a comprehensive framework to classify ncRNA–host-cell interactions for emerging viruses and diseases. In this sense, we introduced them to organize DENV–host-cell interactions.

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