Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation
Jørgen Ankill,
Zhi Zhao,
Xavier Tekpli
et al.
Abstract:Aberrant DNA methylation contributes to gene expression deregulation in cancer. However, these alterations precise regulatory role and clinical implications are still not fully understood. In this study, we performed expression-methylation Quantitative Trait Loci (emQTL) analysis to identify deregulated cancer-driving transcriptional net-works linked to CpG demethylation pan-cancer. By analyzing 33 cancer types from The Cancer Genome Atlas, we identified and confirmed significant correlations between CpG methy… Show more
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