Integrative pan cancer analysis reveals the importance of CFTR in lung adenocarcinoma prognosis

Shi, Xiaoshun; Kou, Mengying; Dong, Xiaoying; Zhai, Jianxue; Liu, Xiguang; Lu, Di; Ni, Zhen; Jiang, Jianjun; Cai, Kaican

doi:10.1016/j.ygeno.2022.110279

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Our patient did not only suffer from hormonal deficiency but also had a history of CF. While the literature often mentions an association between CF and various types of cancer, mainly gastrointestinal tumors, but also skin, lung, hematological and breast cancers, there is no evidence of an association between CF and brain tumors or cystic teratomas in general [ 56 – 68 ].…”

Section: Discussionmentioning

confidence: 99%

Pediatric sellar teratoma – Case report and review of the literature

Kürner,

Greuter,

Roethlisberger

et al. 2024

Childs Nerv Syst

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Background Intracranial teratoma represents a rare neoplasm, occurring predominantly during childhood. Characteristic symptoms depend on the location but are mainly hydrocephalus, visual disturbances, hypopituitarism, and diabetes insipidus. Initial diagnosis can be challenging due to similar radiological features in both teratomas and other lesions such as craniopharyngiomas. Gross total resection is recommended if feasible and associated with a good prognosis. Case description A 10-year-old girl presented with newly diagnosed growth retardation, fatigue, cephalgia and bilateral hemianopia. Further laboratory analysis confirmed central hypothyroidism and hypercortisolism. Cranial magnetic resonance imaging showed a cystic space-occupying lesion in the sellar and suprasellar compartment with compression of the optic chiasm without hydrocephalus present, suspicious of craniopharyngioma. Subsequently, an endonasal endoscopic transsphenoidal near-total tumor resection with decompression of the optic chiasm was performed. During postoperative recovery the patient developed transient diabetes insipidus, the bilateral hemianopia remained unchanged. The patient could be discharged in a stable condition, while hormone replacement for multiple pituitary hormone deficiency was required. Surprisingly, histopathology revealed conspicuous areas of skin with formation of hairs and squamous epithelia, compatible with a mature teratoma. Conclusions We present an extremely rare case of pediatric sellar teratoma originating from the pituitary gland and a review of literature focusing on the variation in presentation and treatment. Sellar teratomas are often mistaken for craniopharyngioma due to their similar radiographic appearances. However, the primary goal of treatment for both pathologies is to decompress eloquent surrounding structures such as the optic tract, and if applicable, resolution of hydrocephalus while avoiding damage to the pituitary stalk and especially the hypothalamic structures. If feasible, the aim of surgery should be gross total resection.

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Section: Discussionmentioning

confidence: 99%

Pediatric sellar teratoma – Case report and review of the literature

Kürner,

Greuter,

Roethlisberger

et al. 2024

Childs Nerv Syst

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“…Notably, the functional importance of a number of the genes in LUAD has been reported. CFTR mutations are closely associated with cystic fibrosis and tumorigenesis of lung cancer ( 45 , 46 ). EREG induces EGFR/ErbB2 heterodimer formation to phosphorylate AKT and block TKI-mediated apoptosis in NSCLC ( 47 ), whereas SFTPD inhibits the dimerization and activation of EGFR ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of a novel endocytosis‑associated gene signature for prognostic prediction in lung adenocarcinoma

Zhang,

Liang,

Zhang

et al. 2023

Oncol Lett

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Lung cancer is one of the most common malignant solid tumors and the leading cause of cancer-associated mortality worldwide. Endocytosis is an essential physiological activity for cells to maintain membrane homeostasis, and has been reported to serve an important role in tumorigenesis and progression. In the present study, the aim was to construct a prognostic prediction model of endocytosis-associated genes for patients with lung adenocarcinoma (LUAD). The endocytosis-associated gene signature was established using Lasso Cox regression analysis using the training set of the LUAD cohort from The Cancer Genome Atlas (TCGA) database, and verified using two datasets from the Gene Expression Omnibus (GEO) database. Kaplan-Meier survival curves were used to evaluate the effectiveness of the prognostic evaluation of patients with LUAD. Differentially expressed genes were screened in the tumor tissue of patients compared with paired paracancerous tissues. A series of candidate genes associated to the prognosis of patients with LUAD was obtained using univariate Cox's regression analysis. Using the Lasso Cox regression analysis, an appropriate risk model with 18 endocytosis-associated genes was established. A high-risk score was positively correlated with a higher tumor stage and pathologic grade. Patients with LUAD and high-risk scores had shorter survival times, increased intratumor heterogeneities and immune cell infiltration into tumor tissues, compared with those patients with LUAD and low-risk scores. The endocytosis inhibitor chloroquine could repress proliferation and increase the apoptosis of lung cancer cells. In summary, a novel endocytosis-associated gene signature was constructed using TCGA and GEO datasets. Patients with LUAD and high-risk scores, as calculated by the signature, had a poor prognosis and short survival time.

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“…The correlation between the core genes and overall survival (OS) in lung cancer was analyzed by Kaplan-Meier plotter (available online: http://www.kmplot.com) (Shi et al, 2022). PrognoScan searches for relationships between gene expression and patient prognosis across a large collection of publicly available cancer microarray datasets.…”

Section: Prognoscan Database Analysismentioning

confidence: 99%

“…The online database GEPIA (http://gepia.cancer-pku.cn/index.html) was used to confirm the significantly correlated genes (Shi et al, 2022). Gene expression correlation analysis was performed for given sets of TCGA expression data.…”

Section: Gene Correlation Analysis In Gepiamentioning

confidence: 99%

AXIN1/MYC Axis Mediated the Osimertinib Resistance in EGFR Mutant Non-Small Cell Lung Cancer Cells

Yu,

Wang,

Dong

et al. 2024

Tohoku J. Exp. Med.

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Osimertinib, a promising and approved third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is a standard strategy for EGFRmutant non-small cell lung cancer (NSCLC) patients. However, developed resistance is unavoidable, which reduces its long-term effectiveness. In this study, RNA sequencing was performed to analyze differentially expressed genes (DEGs). The PrognoScan database and Gene Expression Profiling Interactive Analysis (GEPIA) were used to identify the key genes for clinical prognosis and gene correlation respectively. Protein expression was determined by Western blot analysis. Cell viability assay and Ki67 staining were used to evaluate the effect of osimertinib on tumor cells. Finally, we screened out two hub genes, myelocytomatosis oncogene (Myc) and axis inhibition protein 1 (Axin1), upregulated in three osimertinib-resistant cell lines through RNA sequencing and bioinformatics analysis. Next, cell experiment confirmed that expression of C-MYC and AXIN1 were elevated in different EGFR mutant NSCLC cell lines with acquired resistance to osimertinib, compared with their corresponding parental cell lines. Furthermore, we demonstrated that AXIN1 upregulated the expression of C-MYC and mediated the acquired resistance of EGFR mutant NSCLC cells to osimertinib in vitro. In conclusion, AXIN1 affected the sensitivity of EGFR mutant NSCLC to osimertinib via regulating C-MYC expression A c c e p t e d M a n u s c r i p t 3 in vitro. Targeting AXIN1/MYC signaling may be a potential new strategy for overcoming acquired resistance to osimertinib.

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Integrative pan cancer analysis reveals the importance of CFTR in lung adenocarcinoma prognosis

Cited by 8 publications

References 32 publications

Pediatric sellar teratoma – Case report and review of the literature

Pediatric sellar teratoma – Case report and review of the literature

Identification of a novel endocytosis‑associated gene signature for prognostic prediction in lung adenocarcinoma

AXIN1/MYC Axis Mediated the Osimertinib Resistance in EGFR Mutant Non-Small Cell Lung Cancer Cells

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