Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy

Anđelić, Mirna; Marcuzzo, Stefania; Marchi, Margherita; Lombardi, Raffaella; Cartelli, Daniele; Cazzato, Daniele; Mehmeti, Elkadia; Gelemanović, Andrea; Paolini, Matilde; Pardo, Carlotta; D’Amato, Ilaria; Hoeijmakers, Janneke G. J.; Dib-Hajj, Fadia; Waxman, Stephen G.; Faber, Catharina G.; Lauria, Giuseppe

doi:10.1093/brain/awad025

Cited by 2 publications

(2 citation statements)

References 104 publications

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“… 255 , 256 Altogether, the ectopic levels of non-coding RNAs have great potential in pain evaluation. 257 Correction of abnormal non-coding RNA networks using gene editing and chemical treatment has achieved favorable outcomes for nociceptive, nociplastic and neuropathic pain as shown in preclinical research. 258 – 260 Future clinical trials are eagerly required to promote the translational application of non-coding RNAs.…”

Section: Molecular Mechanisms Of Pain Modulationmentioning

confidence: 99%

Pathology of pain and its implications for therapeutic interventions

Cao,

Xu,

Shi

et al. 2024

Sig Transduct Target Ther

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Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessment and treatment fall short of clinical needs. Benefiting from advances in neuroscience and biotechnology, the neuronal circuits and molecular mechanisms critically involved in pain modulation have been elucidated. These research achievements have incited progress in identifying new diagnostic and therapeutic targets. In this review, we first introduce fundamental knowledge about pain, setting the stage for the subsequent contents. The review next delves into the molecular mechanisms underlying pain disorders, including gene mutation, epigenetic modification, posttranslational modification, inflammasome, signaling pathways and microbiota. To better present a comprehensive view of pain research, two prominent issues, sexual dimorphism and pain comorbidities, are discussed in detail based on current findings. The status quo of pain evaluation and manipulation is summarized. A series of improved and innovative pain management strategies, such as gene therapy, monoclonal antibody, brain-computer interface and microbial intervention, are making strides towards clinical application. We highlight existing limitations and future directions for enhancing the quality of preclinical and clinical research. Efforts to decipher the complexities of pain pathology will be instrumental in translating scientific discoveries into clinical practice, thereby improving pain management from bench to bedside.

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Section: Molecular Mechanisms Of Pain Modulationmentioning

confidence: 99%

Pathology of pain and its implications for therapeutic interventions

Cao,

Xu,

Shi

et al. 2024

Sig Transduct Target Ther

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show abstract

“…Lastly, examination of expression of miRNAs in epidermis strongly discriminating pain patients from healthy individuals ( 563 ). In addition to providing a means to stratify patients prior to treatment, the above techniques also provide information concerning the effectiveness of therapeutic intervention.…”

Section: Improved Basic Science Approachesmentioning

confidence: 99%

Neuropathic pain; what we know and what we should do about it

Smith

2023

Front. Pain Res.

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Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of immunocompetent cells into the site of injury, spinal cord and higher sensory structures such as thalamus and cingulate and sensory cortices. Various cytokines, chemokines, growth factors, monoamines and neuropeptides effect two-way signalling between neurons, glia and immune cells. This promotes sustained hyperexcitability and spontaneous activity in primary afferents that is crucial for onset and persistence of pain as well as misprocessing of sensory information in the spinal cord and supraspinal structures. Much of the current understanding of pain aetiology and identification of drug targets derives from studies of the consequences of peripheral nerve injury in rodent models. Although a vast amount of information has been forthcoming, the translation of this information into the clinical arena has been minimal. Few, if any, major therapeutic approaches have appeared since the mid 1990's. This may reflect failure to recognise differences in pain processing in males vs. females, differences in cellular responses to different types of injury and differences in pain processing in humans vs. animals. Basic science and clinical approaches which seek to bridge this knowledge gap include better assessment of pain in animal models, use of pain models which better emulate human disease, and stratification of human pain phenotypes according to quantitative assessment of signs and symptoms of disease. This can lead to more personalized and effective treatments for individual patients. Significance statement: There is an urgent need to find new treatments for neuropathic pain. Although classical animal models have revealed essential features of pain aetiology such as peripheral and central sensitization and some of the molecular and cellular mechanisms involved, they do not adequately model the multiplicity of disease states or injuries that may bring forth neuropathic pain in the clinic. This review seeks to integrate information from the multiplicity of disciplines that seek to understand neuropathic pain; including immunology, cell biology, electrophysiology and biophysics, anatomy, cell biology, neurology, molecular biology, pharmacology and behavioral science. Beyond this, it underlines ongoing refinements in basic science and clinical practice that will engender improved approaches to pain management.

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Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy

Cited by 2 publications

References 104 publications

Pathology of pain and its implications for therapeutic interventions

Pathology of pain and its implications for therapeutic interventions

Neuropathic pain; what we know and what we should do about it

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