Integrative computational modeling to unravel novel potential biomarkers in hepatocellular carcinoma

Walakira, Andrew; Skubic, Cene; Nadižar, Nejc; Rozman, Damjana; Režen, Tadeja; Mraz, Miha; Moškon, Miha

doi:10.1016/j.compbiomed.2023.106957

Cited by 6 publications

(1 citation statement)

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“…The enzyme encoded by the pipecolic acid and sarcosine oxidase ( PIPOX ) gene is involved in the metabolism of uracil and dihydropyrimidine, which are intermediate products of purine metabolism. Gene mutation in PIPOX may lead to abnormal purine metabolism, and then cause related diseases [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Promotes the Production of Xanthophyll Compounds in Yellow Abdominal Fat through HAAO

Liu,

Men,

Chen

et al. 2024

Animals

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Abdominal fat, which in the past was often regarded as waste and discarded, has in recent years been used as a fat source to produce meat by-products. Yellow abdominal fat has higher economic value. Therefore, improving the color of abdominal fat plays an important role in improving the appearance of meat products. This study aimed to identify the contributors and the regulatory network involved in the formation of yellow and white color in abdominal fat. We found that four xanthophyll compounds were significantly different in yellow and white abdominal fat chicken, including zeaxanthin, lutein, canthaxanthin, and β-cryptoxanthin. There were 551 different and 8 common metabolites significantly correlated with these 4 xanthophyll compounds. Similarly, a total of 54 common genes were identified in 4 common related pathways (Complement and coagulation cascades, Metabolic pathways, PPAR signaling pathway, Carbon metabolism) of the 8 common metabolites. The high expression of HAAO in the yellow abdominal fat group leads to the degradation of tryptophan and its intermediate 5-hydroxyindole, and subsequently to the formation of the four xanthophyll compounds. This process is also regulated by tyrosine, kynurenine 3-monooxygenase (KMO), homogentisate 1, 2-dioxygenase (HGD), etc. Together, these findings show the effect of tryptophan on abdominal fat color, as well as a negative regulatory effect of HAAO and 5-hydroxyindole on the production of xanthophyll compounds involved in abdominal fat coloration.

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Section: Discussionmentioning

confidence: 99%