Integrative Approaches to the Treatment of Cancer

O’Brien, Kylie; Ried, Karin; Binjemain, Taufiq; Sali, Avni

doi:10.3390/cancers14235933

Cited by 14 publications

(4 citation statements)

References 219 publications

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“…Causes of cancer can include genetic mutations, exposure to certain substances or radiation, and certain lifestyle choices [ 18 ]. Early detection and proper treatment can improve outcomes for many people with cancer [ 19 ]. Surgery combined with adjuvant treatment including chemotherapy is currently the most effective strategy for breast cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Mir-153-3p Modulates the Breast Cancer Cells’ Chemosensitivity to Doxorubicin by Targeting KIF20A

Rahman

Yang

Azam

et al. 2023

Cancers

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Breast cancer is considered the solid tumor most sensitive to chemotherapy. However, it can become resistant to various chemotherapeutic drugs, including doxorubicin, which triggers cell death by intercalation between DNA bases, free radical formation, and topoisomerase II inhibition. When drug resistance develops, several miRNAs are dysregulated, suggesting that miRNAs may play a significant role in resistance formation. In the current study, we investigated how doxorubicin sensitivity of breast cancer cells is affected by miR-153-3p and its target gene. The MTT method was used to determine the chemo-sensitizing effect of miR-153-3p on doxorubicin in MCF-7 and MDA-MB-231 cell lines. Results of Western blot and dual luciferase confirmed that miR-153-3p targets KIF20A and decreases its expression. Transwell and flow cytometry experiments showed that miR-153-3p and doxorubicin together had higher effects on MCF-7 and MDA-MB-231 cell proliferation, migration, and invasion, as well as increasing apoptosis and arresting cells in the G1 phase. Proteins related to apoptosis and the cell cycle exhibited the same tendency. Intracellular vesicle formation was inhibited and RAB26 was also downregulated by treatment with miR-153-3p alone or in combination with doxorubicin. Doxorubicin’s ability to suppress tumors may be enhanced by miR-153-3p, according to in vivo studies. According to our findings, miR-153-3p has a direct effect on KIF20A and may regulate the formation of intracellular vesicles, which in turn makes breast cancer cells more susceptible to doxorubicin.

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Section: Discussionmentioning

confidence: 99%

Mir-153-3p Modulates the Breast Cancer Cells’ Chemosensitivity to Doxorubicin by Targeting KIF20A

Rahman

Yang

Azam

et al. 2023

Cancers

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“…Such an approach may include herbal medicine, stress reduction practices, supplements, and physical therapies tailored to the individual patient's needs. By addressing modifiable factors like stress, poor nutrition, physical inactivity, and vitamin deficiencies, oncologists can contribute to better overall patient health and improved treatment outcomes [23].…”

Section: Integrating Medicine and Surgery In Oncologymentioning

confidence: 99%

Oncological Horizons: The Synergy of Medical and Surgical Innovations in Cancer Treatment

Shams,

Abdallah,

Alsadoun

et al. 2023

Cureus

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The landscape of cancer treatment has witnessed a remarkable transformation in recent years, marked by the convergence of medical and surgical innovations. Historically, cancer therapy faced challenges, including limited efficacy and severe side effects. This narrative review explores the historical progression of cancer treatments, shedding light on significant breakthroughs in both medical and surgical oncology. It comprehensively addresses the medical domain, covering chemotherapy, targeted therapies, immunotherapy, hormonal treatments, and radiological procedures. Simultaneously, it delves into the surgical realm, discussing the evolution of surgical techniques, minimally invasive procedures, and the role of surgery across various stages of cancer. The article emphasizes the fusion of medical and surgical approaches, highlighting neoadjuvant and adjuvant therapies and the significance of multidisciplinary tumor boards. It also addresses innovations, challenges, and the pivotal role of patient-centered care. Furthermore, it offers insights into the future directions and forecasts in the constantly evolving field of integrated oncological care. This review provides a comprehensive understanding of the dynamic and transformative nature of cancer treatment, reflecting the unwavering commitment of the medical and surgical communities in the ongoing fight against cancer.

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“…Cancer is a complex and multi-faceted disease that requires a comprehensive and integrated approach to treatment and management (18). It typically involves a combination of surgical, medical, and radiation therapies, as well as supportive care to manage symptoms and improve quality of life.…”

Section: Definition and Epidemiology Of Cancermentioning

confidence: 99%

Cancer and COVID-19: A Double Burden on the Healthcare System

2023

ircmj

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The COVID-19 pandemic has placed an unprecedented burden on the healthcare system. In particular, the intersection of COVID-19 and cancer has created a double burden on the healthcare system, presenting challenges in both the diagnosis and treatment of cancer. During the pandemic, overcrowding of hospitals and clinics, shortages of PPE and other medical supplies, and the impact of COVID-19 on healthcare workers have all made it more difficult to care for cancer patients. The challenges in cancer diagnosis and screening during the pandemic have included delays in cancer diagnoses, decreased access to cancer screenings, and a decrease in the number of cancer surgeries being performed. Changes in cancer treatment patterns and access to care during COVID-19 have also impacted the treatment outcomes for cancer patients, with a decrease in the number of cancer patients being treated and an increased risk of poor outcomes for those who are being treated. The impact of COVID-19 on healthcare workers and their ability to care for cancer patients has also been significant, with healthcare workers facing increased exposure to the virus, increased workloads, and increased stress and burnout. The double burden of COVID-19 and cancer on the healthcare system has implications for policy and practice, including the need for improved coordination between cancer and COVID-19 response efforts and the need for increased investment in healthcare infrastructure and resources. In conclusion, the COVID-19 pandemic has created a double burden on the healthcare system, with significant challenges in the diagnosis and treatment of cancer. The impact of COVID-19 on healthcare workers and the healthcare system more broadly highlights the need for improved coordination and increased investment in healthcare resources and infrastructure.

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Integrative Approaches to the Treatment of Cancer

Cited by 14 publications

References 219 publications

Mir-153-3p Modulates the Breast Cancer Cells’ Chemosensitivity to Doxorubicin by Targeting KIF20A

Mir-153-3p Modulates the Breast Cancer Cells’ Chemosensitivity to Doxorubicin by Targeting KIF20A

Oncological Horizons: The Synergy of Medical and Surgical Innovations in Cancer Treatment

Cancer and COVID-19: A Double Burden on the Healthcare System

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