Integrative analysis of single-cell and bulk RNA sequencing unveils a machine learning-based pan-cancer major histocompatibility complex-related signature for predicting immunotherapy efficacy
Jia-Lin Feng,
Bo Liang,
Wen-Jie Zheng
et al.
Abstract:Major histocompatibility complex (MHC) could serve as a potential biomarker for tumor immunotherapy, however, it is not yet known whether MHC could distinguish potential beneficiaries. Single‐cell RNA sequencing datasets derived from patients with immunotherapy were collected to elucidate the association between MHC and immunotherapy response. A novel MHCsig was developed and validated using large‐scale pan‐cancer data, including The Cancer Genome Atlas and immunotherapy cohorts. The therapeutic value of MHCsi… Show more
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