Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma

Wu, Gen Sheng; Zhou, Jian; Zhu, Xiaoyan; Tang, Xianzhe; Liu, Jie; Zhou, Qiong; Chen, Ziyuan; Wang, Wanchun; Xiao, Xilin; Wu, Tong

doi:10.18632/aging.204039

Cited by 3 publications

(1 citation statement)

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“…RFC2 is famous for DNA replication and damage repair, and participates in disorder of biological process, such as Williams-Beuren syndrome, type 2 diabetes mellitus, and cancers [ 25 – 27 ]. Previous experimental studies have shown that RFC2 is highly expressed in various cancer, such as sarcoma, diffuse lower-grade gliomas, hepatocellular carcinoma, and CRC [ 18 , 20 , 28 , 29 ]. We also found that RFC2 is overexpressed in CRC tissues compared to normal tissues.…”

Section: Discussionmentioning

confidence: 99%

RFC2 promotes aerobic glycolysis and progression of colorectal cancer

Lou,

Zhang

2023

BMC Gastroenterol

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Background Replication factor C subunit 2 (RFC2) participates in the growth and metastasis of various malignancies. Our study investigated the roles of RFC2 in colorectal cancer (CRC). Results RFC2 expression was upregulated in CRC tissues and cells. High RFC2 expression was associated with poor prognosis. Knockdown RFC2 inhibited proliferation, induced apoptosis, and suppressed migration and invasion of CRC cells. CREB5 was a transcription factor of RFC2, and CREB5 knockdown suppressed RFC2 expression. Furthermore, RFC2 promoted aerobic glycolysis and MET/PI3K/AKT/mTOR pathway. Conclusion RFC2 promoted the progression of CRC cells via activating aerobic glycolysis and the MET/PI3K/AKT/mTOR pathway.

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Section: Discussionmentioning

confidence: 99%

RFC2 promotes aerobic glycolysis and progression of colorectal cancer

Lou,

Zhang

2023

BMC Gastroenterol

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Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Wu,

Xu,

et al. 2023

Aging

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Objective: To investigate the prognostic significance of optic atrophy 1 ( OPA1 ) in pan-cancer and analyze the relationship between OPA1 and immune infiltration in cancer. Results: OPA1 exhibited high expression levels or mutations in various types of tumor cells, and its expression levels were significantly correlated with the survival rate of tumor patients. In different tumor tissues, there was a notable positive correlation between OPA1 expression levels and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Additionally, OPA1 and its related genes were found to be involved in several crucial biological processes, including protein phosphorylation, protein import into the nucleus, and protein binding. Conclusion: OPA1 is highly expressed or mutated in numerous tumors and is strongly associated with protein phosphorylation, patient prognosis, and immune cell infiltration. OPA1 holds promise as a novel prognostic marker with potential clinical utility across various tumor types. Methods: We examined OPA1 expression in pan-cancer at both the gene and protein levels using various databases, including Tumor Immune Estimation Resource 2.0 (TIMER 2.0), Gene Expression Profiling Interactive Analysis (GEPIA2), UALCAN, and The Human Protein Atlas (HPA). We utilized the Kaplan-Meier plotter and GEPIA datasets to analyze the relationship between OPA1 expression levels and patient prognosis. Through the cBioPortal database, we detected OPA1 mutations in tumors and examined their relationship with patient prognosis. We employed the TIMER 2.0 database to explore the correlation between OPA1 expression levels in tumor tissue and the infiltration of cancer-associated fibroblasts in the immune microenvironment. Furthermore, we conducted a gene search associated with OPA1 and performed enrichment analysis to identify the main signaling pathways and biological processes linked to them.

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Construction of a prognostic signature of RFC5 immune-related genes in patients with cervical cancer

Chen,

Xie,

Zhang

et al. 2023

CBM

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BACKGROUND: Cervical cancer (CC) is a malignant tumor threatening women’s health. Replication factor C (RFC) 5 is significantly highly expressed in CC tissues, and the immune microenvironment plays a crucial role in tumor initiation, progression, and metastasis. OBJECTIVE: To determine the prognostic role of RFC5 in CC, analyze the immune genes significantly associated with RFC5, and establish a nomogram to evaluate the prognosis of patients with CC. METHODS: High RFC5 expression in patients with CC was analyzed and verified through TCGA GEO, TIMER2.0, and HPA databases. A risk score model was constructed using RFC5-related immune genes identified using R packages. Combining the risk score model and clinical information of patients with CC, a nomogram was constructed to evaluate the prognosis of patients with CC. RESULTS: Comprehensive analysis showed that the risk score was a prognostic factor for CC. The nomogram could predict the 3-year overall survival of patients with CC. CONCLUSIONS: RFC5 was validated as a biomarker for CC. The RFC5 related immune genes were used to establish a new prognostic model of CC.

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Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma

Cited by 3 publications

References 50 publications

RFC2 promotes aerobic glycolysis and progression of colorectal cancer

RFC2 promotes aerobic glycolysis and progression of colorectal cancer

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Construction of a prognostic signature of RFC5 immune-related genes in patients with cervical cancer

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