Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence

Sunkel, Benjamin; Wu, Dayong; Chen, Zhong; Wang, Chiou‐Miin; Liu, Xiangtao; Ye, Zhenqing; Horning, Aaron M.; Liu, Joseph K.; Mahalingam, Devalingam; Lopez-Nicora, Horacio D.; Lin, Chun-Lin; Goodfellow, Paul J.; Clinton, Steven K.; Jin, Victor X.; Chen, Chun-Liang; Huang, Tim H-M.; Wang, Qianben

doi:10.1093/nar/gkx282

Cited by 11 publications

(9 citation statements)

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“…The presence of the same target gene in the three cell lines subjected to invasion suggests a key role for the CREB1 gene in the invasion process regardless of cell type. It has been described several times, in fact, how this transcription factor is involved in various cancer, raising its level in the advanced stages of the disease, being predictive of relapse and correlated with poor outcomes [71][72][73]. Through the analyses performed with GEPIA we did not observe a significant differential expression of the CREB1 gene in both breast and prostate patients (Figure 8c).…”

Section: Discussionmentioning

confidence: 73%

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells

Lessi

Aretini

Rizzo

et al. 2021

Cell Adhesion & Migration

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Section: Discussionmentioning

confidence: 73%

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells

Lessi

Aretini

Rizzo

et al. 2021

Cell Adhesion & Migration

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“…These data consolidate that CREB1 is essential for anticancer effects of imperatorin. Although CREB1 has been reported to play an important role in tumor development and progression in other cancer types, [27][28][29][30] the clinical relevance of CREB1 in ESCC remains unknown. Here, we found that high CREB1 in ESCC is correlated with poor survival of patients, suggesting the rationale of taking CREB1 as a therapeutic target for anti-metastasis drug.…”

Section: Discussionmentioning

confidence: 99%

Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

Huang

Liao

et al. 2020

Advanced Science

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Metastasis accounts for 90% of cancer death worldwide, and effective therapeutic strategies are lacking. The aim of this work is to identify the key drivers in tumor metastasis and screen therapeutics for treatment of esophageal squamous cell carcinoma (ESCC). Gene Ontology analysis of The Cancer Genome Atlas (TCGA) gene expression datasets of ESCC patients with or without lympy metastasis identifies that TGF 2 is highly enriched in the pathways essential for tumor metastasis and upregulates in the metastatic ESCC tumors. High TGF 2 expression in ESCC correlates with metastasis and patient survival, and functionally contributes to tumor metastasis via activating extracellular signal-regulated kinases (ERK) signaling. By screening of a library consisting of 429 bioactive compounds, imperatorin is verified as a novel TGF 2 inhibitor, with robustly suppressive effect on tumor metastasis in multiple mice models. Mechanistically, direct binding of imperatorin and CREB1 inhibits phosphorylation, nuclear translocation of CREB1, and its interaction with TGF 2 promoter, represses TGF 2 expression and fibroblasts-secreted CCL2, and then inactivates ERK signaling to block cancer invasion and abrogates the paracrine effects of fibroblasts on tumor angiogenesis and metastasis. Overall, the findings suggest the use of TGF 2 as a diagnostic and prognostic biomarker and therapeutic target in ESCC, and supports the potential of imperatorin as a novel therapeutic strategy for cancer metastasis.

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“…In this study, circCASC15 could function as a miRNA sponges for miR-1224-5p and regulate the expression of the downstream gene CREB1. Many studies have shown that CREB1 played oncogenic roles to promote cell proliferation in different kinds of cancers including BC (23)(24)(25)(26)(27). Thus, we suspected that circCASC15 promoted cell proliferation through activating downstream CREB1 expression.…”

Section: Discussionmentioning

confidence: 90%

Circular RNA hsa_circ_0075828 Promotes Bladder Cancer Cell Proliferation Through Activation of CREB1

Zhuang

Huang

et al. 2020

BMB Rep.

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Circular RNAs (circRNAs), one kind of non-coding RNA, have been reported as critical regulators for modulating gene expression in cancer. In this study, microarray analysis was used to screen circRNA expression profiles of bladder cancer (BC) 5637 cells, T24 cells and normal control SV-HUC-1 cells. The data from the microarray showed that hsa_circ_0075828 (named circCASC15) was most highly expressed in 5637 and T24 cells. circCASC15 was highly expressed in BC tissues and cells. Overexpression of circCASC15 was closely associated with BC tumor stage and promoted cell proliferation significantly in vitro and in vivo. Mechanistically, circCASC15 could act as miR-1224-5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. In short, circCASC15 promotes cell proliferation in BC, which might be a new molecular target for BC diagnosis and therapy. [BMB Reports 2020; 53(2): 82-87] BMB Rep. 2020; 53(2): 82-87 www.bmbreports.org hsa_circ_0075828 promotes proliferation in BC Chengle Zhuang, et al.

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Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence

Cited by 11 publications

References 0 publications

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells

Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells

Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2‐ERK Signaling to Suppress Esophageal Cancer Metastasis

Circular RNA hsa_circ_0075828 Promotes Bladder Cancer Cell Proliferation Through Activation of CREB1

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