Integration of the Immune System into Complex In Vitro Models for Preclinical Drug Development

Ekert, Jason E.; Mohanan, Sunish; Deakyne, Julianna S.; Allen, Philippa Pribul; Marshall, Nikki B.; Jeong, Claire G.; Getsios, Spiro

doi:10.1201/9780367814809-18

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After this stage, any initial hits identified can be validated further with OoC models that are higher throughput but still more complex than 2D systems to identify lead molecules. Later, at the lead optimisation and candidate selection phase, these OoC models support decision making for more effective and safer candidates to be progressed further into the development phase [ 5 ]. For target validation, candidate selection and safety assessment, the low throughput of the complex systems is not necessarily a bottleneck per se as recapitulating the multiparametric readouts of the human in vivo healthy and disease situation is more important which are reserved to animal models.…”

Section: Ooc In Early Stage Research and Drug Discoverymentioning

confidence: 99%

Organ-on-a-chip: current gaps and future directions

Çandarlıoğlu

Negro

Hughes

et al. 2022

Biochemical Society Transactions

View full text Add to dashboard Cite

As an emerging hot topic of the last decade, Organ on Chip (OoC) is a new technology that is attracting interest from both basic and translational scientists. The Biochemical Society, with its mission of supporting the advancement of science, with addressing grand challenges that have societal impact, has included OoC into their agenda to review the current state of the art, bottlenecks and future directions. This conference brought together representatives of the main stakeholders in the OoC field including academics, end-users, regulators and technology developers to discuss and identify requirements for this new technology to deliver on par with the expectations and the key challenges and gaps that still need to be addressed to achieve robust human-relevant tools, able to positively impact decision making in the pharmaceutical industry and reduce overreliance on poorly predictive animal models.

show abstract

Section: Ooc In Early Stage Research and Drug Discoverymentioning

confidence: 99%