Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin infection; D-optimal optimization, ex-vivo, in-silico, and in-vivo studies

El-Naggar, Moaz M.; El-Nabarawi, Mohamed A.; Teaima, Mahmoud H.; Hassan, Mariam; Hamed, Mohammed I. A.; El-Rashedy, Ahmed A.; Albash, Rofida

doi:10.1016/j.ijpharm.2023.122621

Cited by 11 publications

(4 citation statements)

References 71 publications

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“…It was tested for visual, EE%, PS, PDI, and ZP alterations before and after storage. The gathered data were statistically examined utilizing the Student's t-test in SPSS ® program 22.0 [63,64] The current investigation was carried out in accordance with the guidelines for the care and use of laboratory animals approved by the Research Ethical Committee, Faculty of Pharmacy, October 6 University, Egypt (PRE-Ph-2212046). A total of 70 adult female Swiss Albino mice weighing 20-25 g were acquired from the National Research Center (Cairo, Egypt).…”

Section: Effect Of Short-term Storagementioning

confidence: 99%

Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study

Elmahboub,

Albash,

Magdy William

et al. 2024

Molecules

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Metformin (MET), an antidiabetic drug, is emerging as a promising anticancer agent. This study was initiated to investigate the antitumor effects and potential molecular targets of MET in mice bearing solid Ehrlich carcinoma (SEC) as a model of breast cancer (BC) and to explore the potential of zein nanoparticles (ZNs) as a carrier for improving the anticancer effect of MET. ZNs were fabricated through ethanol injection followed by probe sonication method. The optimum ZN formulation (ZN8) was spherical and contained 5 mg zein and 30 mg sodium deoxycholate with a small particle size and high entrapment efficiency percentage and zeta potential. A stability study showed that ZN8 was stable for up to three months. In vitro release profiles proved the sustained effect of ZN8 compared to the MET solution. Treatment of SEC-bearing mice with ZN8 produced a more pronounced anticancer effect which was mediated by upregulation of P53 and miRNA-543 as well as downregulation of NF-κB and miRNA-191-5p gene expression. Furthermore, ZN8 produced a marked elevation in pAMPK and caspase-3 levels as well as a significant decrease in cyclin D1, COX-2, and PGE2 levels. The acquired findings verified the potency of MET-loaded ZNs as a treatment approach for BC.

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Section: Effect Of Short-term Storagementioning

confidence: 99%

Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study

Elmahboub,

Albash,

Magdy William

et al. 2024

Molecules

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“…Moreover, levocetirizine hydrochloride was recently approved its efficacy against bacterial skin infection with Methicillin-Resistant Staphylococcus aureus by formulating the drug into terpene enriched vesicles 4 . Another study performed by Albash et al proved the enhanced repurposed effect of spironolactone for reducing hair production and as a treatment for hirsutism using hyaluronic acid enriched cerosomes 59 .…”

Section: Antineoplastic Agentsmentioning

confidence: 99%

“…Drug repurposing, which is also referred to as drug repositioning, implies identifying novel medical applications for drugs that are already recognized. This includes approved, discontinued, and experimental drugs 4 . Although the technique is not new, it has acquired massive popularity during the last decade.…”

Section: Introductionmentioning

confidence: 99%

Advances and Developments in Drug Repurposing; State of Art

noori,

Al-Hamdani,

kassem

2023

Bulletin of Pharmaceutical Sciences Assiut University

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Although the rapid progress in science and technology, developing new drugs from scratch has been expensive in recent decades. As a result, drug-repurposing, which implies seeking new utilizes for presently approved drugs instead of discovering new drug compounds, has emerged as a substitution tool to speed up the drug development procedure. Nowadays, drug repurposing accounts for 30% of newly approved drugs. With the explosive growth of pharmacological compounds' molecular, genomic, and phenotypic data, a novel area of drug repurposing called computational drug repurposing has emerged. This review provides an overview of recent progress in computational drug repurposing, including repositioning approaches, commonly used computational methods, validation techniques for repurposing studies, and the remaining encounters in computational repurposing. In this Review, we outline methods for drug repurposing (also known as drug repositioning), talk about difficulties encountered by the repurposing community, and suggest creative solutions to these issues. addressed to aid in maximising the benefits of medicinal repurposing.

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“…To keep the volume constant of the release media, aliquots of 5 ml were taken out at predefined intervals up to 12 hrs and replaced with fresh medium. The samples were diluted, filtered using a millipore filter (0.45 m), and then subjected to UV/VIS spectrophotometer analysis at 274 nm using spectrophotometer (model UV-1601 PC; Shimadzu) 15 .…”

Section: Drug Loading % = × 100mentioning

confidence: 99%

Evaluation and Preparation of Atenolol-Loaded Floating Microcapsules

hammodi,

El-Dahan,

Borg

2023

Bulletin of Pharmaceutical Sciences Assiut University

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The aim of this investigation is to prepare Atenolol (AT) floating microcapsules with sustained release profiles utilizing ethyl cellulose (EC) as a matrix former. EC is frequently used as a hydrophobic polymeric material for extended drug release applications. Emulsionsolvent evaporation technique was utilized to fabricate the floating microcapsules. The ratios of EC and AT utilized were 1:1, 1:2, 1:3, 1:4, and 1:5, with the amount of EC used being constant and the amount of AT being variable depending on the polymer ratio/AT ratio. The prepared microcapsules were assessed for entrapment efficiency (EE%), drug loading, percent yield (% yield), buoyancy percentage (%), particle size analysis, and in-vitro drug release study after 12 h. After that, the best-achieved microcapsule was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The best formula (M1) demonstrated a spherical morphology. Further, M1 released about 91.23 ± 3.21% after 12 h. Moreover, the FTIR showed that their no chemical interaction between the formulation components. In addition, DSC showed the ability of microcapsules to enclose AT inside its constructs. Further, XRD studies showed that microcapsules had an amorphous form. The previous findings demonstrated the good capability of M1 as a floating dosage form for sustained and continuous drug delivery of AT.

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Integration of terpesomes loaded Levocetrizine dihydrochloride gel as a repurposed cure for Methicillin-Resistant Staphylococcus aureus (MRSA)-Induced skin infection; D-optimal optimization, ex-vivo, in-silico, and in-vivo studies

Cited by 11 publications

References 71 publications

Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study

Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study

Advances and Developments in Drug Repurposing; State of Art

Evaluation and Preparation of Atenolol-Loaded Floating Microcapsules

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