Integration of Osteoclastogenesis through addition of PBMCs in Human Osteochondral Explants culturedEx vivo
Esther E.A. Cramer,
Bregje W.M. de Wildt,
Johannes G.E. Hendriks
et al.
Abstract:The preservation of tissue specific cells in their native 3D extracellular matrix in bone explants provides a unique platform to study remodeling. Thus far, studies involving bone explant cultures showed a clear focus on achieving bone formation and neglected osteoclast activity and resorption. To simulate the homeostatic bone environment ex vivo, both key elements of bone remodeling need to be represented. This study aimed to assess and include osteoclastogenesis in human osteochondral explants through medium… Show more
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